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Esophageal Strictures

Esophageal Strictures. William Stanford – Leader & BSAC Daniel Frost – BWIG Thomas Fleming – Communicator Client: Dr. Mark Reichelderfer, MD Advisor: Professor John Webster. Presentation Outline. Problem Statement Background Information Current Methods Design Constraints

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Esophageal Strictures

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  1. Esophageal Strictures William Stanford – Leader & BSAC Daniel Frost – BWIG Thomas Fleming – Communicator Client: Dr. Mark Reichelderfer, MD Advisor: Professor John Webster

  2. Presentation Outline • Problem Statement • Background Information • Current Methods • Design Constraints • Possible Designs • Future Work

  3. Background Information • Esophageal Stricture • Stomach acid reflux into esophagus forms stricture • Also from cancer, lung problems, and genetics • Causes heartburn • Treatment • Surgery and dilation • Surgery is complicated and risky • Dilation is more safe • Inflatable balloon inside the esophagus

  4. Background Information • Stricture Size and Compliance • Compliance = Volume/Pressure • Little work has been done involving compliance • Compliance gives information about scar tissue • Can lead to better treatment options • Potential correlation between stricture types

  5. Problem Statement • Device should: • Measure pressure in balloon • Measure change in volume of syringe • Graph volume/pressure curve in real time • Be aesthetically pleasing for hospital setting • Eventually be commercially available

  6. Design Constraints • Work with current dilation procedure • Provide real time data • Provide warning of esophageal perforation • Software that runs on hospital computers • Compliance accurate to three significant figures • Compact enough for hospital setting • Safety

  7. Current Prototype • Syringe is filled with saline • Pressure measured with pressure transducer • Volume measured with linear potentiometer • Outputs are connected to an amplifier circuit • Circuit connects to computer

  8. Design 1: LabView • Advantages: • Real time graphing • Reads two inputs • Automatically converts units • Simple inputs • Image oriented programming • Disadvantages: • Complicated • Time consuming to learn • Relatively expensive

  9. Design 2: BioBench • Advantages: • No programming required • Has a playback mode • Multiple inputs • Less expensive • Disadvantages: • No real time graphing • No automatic unit conversion • Data has to be exported in Microsoft Excel

  10. Design 3: Pasco • Advantages: • Real time graphing • Data can be entered into equations • Easy to use • Two inputs • Least expensive • Disadvantages: • No support for saline pressure sensor

  11. Design Matrix

  12. Future Work • Write software program for graphing • Develop amplification circuit • Testing • Aesthetic finalization • Gain IRB approval • Human testing

  13. References • http://sine.ni.com/nips/cds/view/p/lang/en/nid/1454 • http://en.wikipedia.org/wiki/Image:Labview-logo.png • http://www.pasco.com • Hale, A. et. al. (2002). Barostat to Measure Esophageal Strictures. • Kirking, H. et. al. (2002). Barostat to Measure Esophageal Strictures. • Seashore, K. et. al. (2006). Device for Dilating Esophageal Strictures.

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