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Esophageal Strictures

Esophageal Strictures. William Sanford Karissa Thoma Dan Frost Allie Finney Client: Dr. Mark Reichelderfer Advisor: Dr. Willis Tompkins. Overview. Background Problem Statement Design Constraints Previous design work Lab Jacks Pressure Sensor Sealants Future Work.

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Esophageal Strictures

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  1. Esophageal Strictures William Sanford Karissa Thoma Dan Frost Allie Finney Client: Dr. Mark Reichelderfer Advisor: Dr. Willis Tompkins

  2. Overview • Background • Problem Statement • Design Constraints • Previous design work • Lab Jacks • Pressure Sensor Sealants • Future Work

  3. Esophageal Strictures • Dysphagia= dyswith difficulty +phagiawith eating • Causes • GERD majority • 25% other problems • Eosinophilic esophagitis UW-Hospital, Dr. Mark Reichelderfer

  4. Eosinophilic Esophagitis • Adolescents and young men • History of food and environmental allergies • Difficult to treat: • Associated with mucosal tearing and perforation http://www.nature.com/gimo/contents/pt1/images/gimo49-f4.jpg

  5. Dilation • Balloon • Dilates radially increasing lumen • TTS scope (through the scope) • Perforations Dependent on: • Clinician’s experience • Equipment http://www.dkimages.com/discover/previews/881/28882.JPG http://homepages.cae.wisc.edu/~bme402/esophageal_structures_s06/images/balloondialation.bmp

  6. Problem Statement • Measure pressure in balloon • Graph volume/pressure curve in real time • Obtain test data on tissue compliance • Be aesthetically pleasing for hospital setting • Eventually be commercially available

  7. Design Constraints • Work with current dilation procedure • Provide real time data • Safety • Equip laptop for hospital use • Provide warning of esophageal perforation • Compact enough for hospital setting

  8. Previous Work • Syringe is filled with saline • Pressure measured with disposable pressure transducer • Volume measured with linear potentiometer • Outputs are connected to computer • Designed LabVIEW circuit for real time graph Seashore, K. et. al. (2006). Device for Dilating Esophageal Strictures.

  9. LabVIEW Circuit

  10. Lab Jacks-LabJack U12 • Pros • Built-in power supply • Large input range • LabVIEW compatible • USB-based • Cons • Cost • No -5V supply http://www.labjack.com/labjack_u12.php?prodId=27

  11. PMD-1208LS • Pros • USB • Power supply • LabVIEW compatible • Cons • No -5V supply • Poor user interface http://www-zeuthen.desy.de/apewww/APE/hardware/APEmille/Temperature/PMD-1208LS.pdf

  12. LabJack UE9 Pro • Pros • Wireless transmission • USB • LabVIEW compatible • Cons • Cost • Bulky http://www.labjack.com/labjack_ue9.php?prodId=46

  13. LabJack Matrix

  14. Metal adhesives - MK 1325 • Pros • High strength • Thread sealant • Low viscosity • Cons • Irreversible • From Germany http://www.bestklebstoffe.com/media/datenblaetter/englisch/tiMK1325ERev001.pdf?PHPSESSID=952e86e08d406e9e05a6b976cf39c2e4

  15. Gorilla Glue • Pros • Waterproof • Good for dissimilar surfaces • Thread sealant • Easy to obtain • Cons • Glue expansion http://www.gorillaglue.com/home/gorilla-glue/product-detail.aspx

  16. Megaloc • Pros • 12000 Psi strength • Thread sealant • Non-toxic • Inexpensive • Cons http://www.herchem.com/specs/megaloc.pdf

  17. Sealant Matrix 2

  18. Future Work • Fix pressure sensor • Obtain 10 atm seal • Configure device with Lab Jack • Configure to hospital laptop • IRB approval/testing

  19. References Fass, R. M. (2008). Approach to the patient with dysphagia. Retrieved Jan. 31, 2008 from Moises, G. M. (2008). Complications of esophageal stricture dilation. Retrieved Jan 31, 2008 from Moises, G. M. (2008). Management of benign esophageal strictures. Retrieved Jan. 31 2008, 2008 from www.uptodate.com

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