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Day Date Reading Topic M 1/14 pp185-201 (Ch. 5) C. elegans , model systems, and molecular genetics W 1/16 Ch. 1 An introduction to developmental biology M 1/21 no class – Dr. Rev. Martin Luther King, Jr. Day
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Day Date Reading Topic • M 1/14 pp185-201 (Ch. 5) C. elegans, model systems, and molecular genetics • W 1/16 Ch. 1 An introduction to developmental biology • M 1/21 no class – Dr. Rev. Martin Luther King, Jr. Day • W 1/23 Ch. 1 More introduction and • review / refresher covering gene expression • M 1/28 Ch. 3 Patterning vertebrate axes and germ layers • W 1/30 More patterning vertebrate axes • M 2/4 Ch. 4 Early patterning of vertebrate nervous systems • W 2/6 More early patterning of vertebrate nervous systems • M 2/11 Ch. 14 Overview of developmental mechanisms in evolution • W 2/13 EXAM 1 Chapters 1, 3, 4, and pp185-201 • M 2/18 no class - Winter Break • W 2/20 no class - Winter Break
We will cover this material later in the course. Boxes 3E and 4B
setting up left-right asymmetry Figs. 3.41, 3.42
4.4, 4.5, 4.6 and 4.7 are not very important for us. These cover the timing and patterning of somite development = somitogenesis.
wild-type fruit fly antennapedia mutant Box 4A
The Hox gene family are examples of homeotic genes. Homeotic genes are genes that when mutant cause a change in the spatial position of structures (change in address). wild-type fruit fly antennapedia mutant Box 4A
The Hox gene family are examples of homeotic genes. Homeotic genes are genes that when mutant cause a change in the spatial position of structures (change in address). Box 4A
The Hox gene family are examples of homeotic genes. The Hox gene products give the positional address along the Anterior-Posterior (A/P) axis in all animals. Box 4A
The Hox gene family are examples of homeotic genes. The Hox genes encode a family of paralogous proteins that are sequence-specific DNA-binding transcription factors.
The Hox gene family are examples of homeotic genes. The Hox proteins bind to response elements in the promoter DNA of target genes. The DNA-binding domain of the protein is called the homeodomain:
The Hox gene family are examples of homeotic genes. Hox proteins work in a combinatorial manner to determine A/P axis address. Fig. 4.9
Patterning within each somite Fig. 4.15, 4.16
Patterning within each somite Fig. 4.15, 4.16
Patterning within each somite Fig. 4.15, 4.16