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Synthetic Biology at Saint Mary’s College 1. Previous experience 2. Application in courses

Synthetic Biology at Saint Mary’s College 1. Previous experience 2. Application in courses a. Vidya – Genetics lab course b . Valerie – Special Topics in Chemistry lecture course 3. Research. 3. Research a. Engineered biosynthesis of biologically active natural products

erasmus-copeland
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Synthetic Biology at Saint Mary’s College 1. Previous experience 2. Application in courses

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  1. Synthetic Biology at Saint Mary’s College 1. Previous experience 2. Application in courses a. Vidya – Genetics lab course b. Valerie – Special Topics in Chemistry lecture course 3. Research

  2. 3. Research a. Engineered biosynthesis of biologically active natural products (or precursors) i. Taxol Challenge – work already in progress! ex. Biotechnol. Bioeng.2006, 93, (2) 212-224. ii. Other targets?! Challenge – finding biosynthetic pathways

  3. 3. Research b. Pollutant detectors i. Pyrethroids: very low concentrations are toxic Can synthetic biology provide lower detection methods? challenge – Na+ channel disruptor ii. Endocrine disruptors (herbicides, pesticides, additives) bisphenols; chlordanes; PCBs; etc.

  4. Endocrine disruptors strategy (maybe): Lipid Soluble Drug Hormone Responsive gene HRE HREP GFP • Applications: • Detection of certain endocrine disruptors • Detection limits? • 2. Screening to identify compounds as endocrine disruptors

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