1 / 12

Valproic Acid

Valproic Acid. Software and Presentation by: Ted, Rob, Jeff, Cassie, Tristan, Korin, Ron, Gabe, Matt, Judith, Lindsay. General Information. Used in the management of multiple seizure types. Oral and IV forms

fadhila
Download Presentation

Valproic Acid

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Valproic Acid Software and Presentation by: Ted, Rob, Jeff, Cassie, Tristan, Korin, Ron, Gabe, Matt, Judith, Lindsay

  2. General Information • Used in the management of multiple seizure types. • Oral and IV forms • Also indicated for management of bipolar affective disorder and possible migraine prevention. • Increases body’s production and response to GABA.

  3. Therapeutic / Toxic Conc’s • Cpss range- 50 to 100 mcg/ml. • Upper limit of 175mcg/ml with proper monitoring. • At concentrations >75 mcg/ml some patients may experience adverse effects.

  4. Basic Clinical Pharmacokinetics • Exhibits concentration dependant protein binding • Follows Non-Linear Kinetics • Highly protein bound to albumin • Follows a basic 1-Compartment Model.

  5. Clinical Implications • Clearance is now dose or concentration dependant. • Volume of Distribution is now affected by concentration-dependant plasma protein binding and its value should be 0.15 to 2.0 L/kg. • Half Life 12 to 18 hrs for adults and is found by the eqn. t1/2=0.693xVd/Cl

  6. Software Structure • Functional components of the software were segmented into “tiers” to make the application to support ease of use and maintainability • Core • Peripheral • Variable Core Peripheral Variable

  7. Core Components • Contains foundational assumptions of the software • User Input requirements • Kinetic Models • Changing the Core will cause global changes to functionality and require massive reworking of the system • Intolerant to changes Core Peripheral

  8. Peripheral Components • Contains slowly changing parameters • Changes cascade to most sections of the software • Changes tolerated, but should be rare and hidden from most users • Provides extensibility of the application • Includes reports charts, kinetic parameters Peripheral Core Peripheral

  9. Variable Components • Continuously changing • High tolerance to changes, incorrect / inappropriate input • Patient Cases Core Peripheral Variable

  10. Bayesian Pharmacokinetics • Estimate drug dosage or steady state plasma concentration • Patient’s parameters (age, weight, sex, serum creatine) • Absence of or with measured drug levels • DrugCalc shareware software • Dr. Dennis Mungall • Nonlinear regression • One-compartment model

  11. DrugCalc Example • Enter patient’s demographic, drug dosing, and serum concentration • Compute the pharmacokinetic parameters • Compute desired dose to achieve steady state concentration

  12. Example time

More Related