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Protein Fouling in Vascular Implants Madeline Lok, Matthew Rakochey, Gillian McKercher, Michael Mislan Schulich School of Engineering, University of Calgary. Group 18. Vascular Implants. Clot Formation. Blood-material interactions can lead to the formation of blood clots by two mechanisms
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Protein Fouling in Vascular Implants Madeline Lok, Matthew Rakochey, Gillian McKercher, Michael Mislan Schulich School of Engineering, University of Calgary Group 18 Vascular Implants Clot Formation • Blood-material interactions can lead to the formation of blood clots by two mechanisms • Contact activation occurs when factor FXII comes into contact with a negatively charged surface and changes shape • Platelet activation occurs when Fibrinogen adsorbs to a hydrophobic surface and platelets adhere to the vessel wall Protein Adsorption Implant Biomaterials The success and durability of a vascular implant is extremely dependent on the chosen material. There are six major factors influencing the selectivity of a material: • Interaction with Water • Drug Elution • Surface Charges and Chemical Structure • Stability • Physical Structure • Result in Clinical Trials While the listed thromboresistent characteristics are important, a material’s success in clinical trials is the ultimate determining factor for its production in practical therapy. (will post images) e-PTFE (like Gore-Tex) versus PEO