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Michalska , ATVB, 2012, online

Michalska , ATVB, 2012, online. Leukocyte. VCAM (on EC). Endothelial Cells. Intima. Smooth Muscle Cells. http://www.clinchem.org/content/54/1/24/F1.expansion.html. P03011. VCAM-binding peptide. USPIO. (Contrast Agent for MRI). (targeting motif).

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Michalska , ATVB, 2012, online

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  1. Michalska, ATVB, 2012, online

  2. Leukocyte VCAM (on EC) Endothelial Cells Intima Smooth Muscle Cells http://www.clinchem.org/content/54/1/24/F1.expansion.html

  3. P03011 VCAM-binding peptide USPIO (Contrast Agent for MRI) (targeting motif) http://nihlibrary.ors.nih.gov/ipdcdb/ipdcdb_main.asp?Page=4

  4. SECARS? • Light hits molecule • Molecule energy is shifted up to virtual energy state • Photon emitted when molecule drops down in energy • Anti-Stokes is when energy is less than original • Allows for high resolution imaging http://en.wikipedia.org/wiki/Raman_spectroscopy

  5. t1/2 = 4.0±2.4h t1/2 = 7.2±2.5h t1/2 = 5.0±1.7h t1/2 = 6.0±1.3h

  6. Spleen pre-injection Spleen post-injection DAPI CD68 Liver pre-injection Liver post-injection Prussian blue stains iron Lymph post-injection Lung post-injection kidney post-injection muscle post-injection

  7. Michalska, ATVB, 2012, online

  8. 12 wk 30 wk Michalska, ATVB, 2012, online

  9. Michalska, ATVB, 2012, online

  10. early plaques late plaques Control injection Michalska, ATVB, 2012, online

  11. Michalska, ATVB, 2012, online

  12. Chen, Biomaterials, 2009, 30, 79-88

  13. Chen, Biomaterials, 2009, 30, 79-88

  14. Chen, Biomaterials, 2009, 30, 79-88

  15. Chen, Biomaterials, 2009, 30, 79-88

  16. Chen, Biomaterials, 2009, 30, 79-88

  17. Chen, Biomaterials, 2009, 30, 79-88

  18. Chen, Biomaterials, 2009, 30, 79-88

  19. Chen, Biomaterials, 2009, 30, 79-88

  20. Chen, Biomaterials, 2009, 30, 79-88

  21. Chen, Biomaterials, 2009, 30, 79-88

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