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Synthesis of Biodegradable Nanospheres for Side-Effect-Free Anti-Cancer Drug Delivery (2007)

Synthesis of Biodegradable Nanospheres for Side-Effect-Free Anti-Cancer Drug Delivery (2007). Nicholas Derrico. Background. Cancer causes 13% of all deaths worldwide. Background. Cancer causes 13% of all deaths worldwide Cancer has no cure. Background.

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Synthesis of Biodegradable Nanospheres for Side-Effect-Free Anti-Cancer Drug Delivery (2007)

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  1. Synthesis of Biodegradable Nanospheres forSide-Effect-Free Anti-Cancer Drug Delivery(2007) Nicholas Derrico

  2. Background • Cancer causes 13% of all deaths worldwide

  3. Background • Cancer causes 13% of all deaths worldwide • Cancer has no cure

  4. Background • Cancer causes 13% of all deaths worldwide • Cancer has no cure-all • Chemotherapy dissolves highly toxic drugs into hydrophobic solutions, which are then administered to the patient, killing cells indiscriminately.

  5. Purpose • To develop a cutting-edge, side-effect-free delivery system to encapsulate camptothecin in biodegradable, biocompatible nanospheres that will target only cancer cells

  6. Background • Cancer cells have leaky vasculature

  7. Background • Cancer cells have leaky vasculature <200 nm

  8. Previous Studies • Sheihet (2007) successfully encapsulated the drug paclitaxel

  9. Previous Studies • Sheihet (2007) successfully encapsulated the drug paclitaxel • Gounder (2007) used biodegradable, biocompatible nanospheres to kill cancer in mice without side-effects

  10. Goals • To synthesize nanospheres from ABA-triblock copolymers that are < 200 nm in hydrodynamic diameter

  11. Goals • To synthesize nanospheres from ABA-triblock copolymers that are < 200 nm in hydrodynamic diameter • To determine the composition of ABA-triblock copolymers that will form nanospheres that can hold as much camptothecin as possible

  12. ABA-Triblock Copolymer • Biodegradable

  13. ABA Triblock Copolymer • Biodegradable • Biocompatible

  14. ABA Triblock Copolymer • Biodegradable • Biocompatible • Non-cytotoxic

  15. ABA Triblock Copolymer • Biodegradable • Biocompatible • Non-cytotoxic • Spontaneously self-assemble into nanospheres in aqueous solution

  16. B-Block

  17. Desaminotyrosyl Tyrosine Alkyl Ester

  18. Desaminotyrosyl Tyrosine Alkyl Ester R = Pendant Chains

  19. Desaminotyrosyl TyrosineButylEster

  20. Desaminotyrosyl TyrosineOctylEster

  21. Desaminotyrosyl TyrosineDodecylEster

  22. Desaminotyrosyl TyrosineBenzylEster

  23. Desaminotyrosyl Tyrosine Alkyl Ester

  24. Suberic Acid

  25. B-Block

  26. Poly(ethylene glycol) = A-Block

  27. Self-Assembling into Nanospheres A-Block B-Block

  28. Self-Assembling into Nanospheres

  29. Self-Assembling into Nanospheres

  30. Self-Assembling into Nanospheres =

  31. Self-Assembling into Nanospheres

  32. Self-Assembling into Nanospheres

  33. Self-Assembling into Nanospheres

  34. Self-Assembling into Nanospheres

  35. Self-Assembling into Nanospheres

  36. Compositions

  37. Compositions

  38. Results Camptothecin Only Nanospheres

  39. Results Camptothecin Only Nanospheres

  40. Figure 5: VD3 Binding Efficiency of 3 best copolymer compositions Binding Efficiencies of Vitamin D3

  41. Figure 4: CPT Binding Efficiency of 3 best copolymer compositions Binding Efficiencies of Camptothecin

  42. Conclusion • 15% camptothecin was encapsulated

  43. Conclusion • 15% camptothecin was encapsulated • Pelleting occurred during ultracentrifugation

  44. Future Study • Use ultrafiltration in procedure

  45. Acknowledgements • Team Research • Larisa Sheihet Ph.D • Will Mallon • Ms. Lois Fruen

  46. Questions?

  47. Synthesis of Biodegradable Nanospheres forSide-Effect-Free Anti-Cancer Drug Delivery(2007) Nicholas Derrico

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