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Biodefense Research: NJMS Center for Biodefense and Emerging Pathogens

The UMDNJ New Jersey Medical School's Center for Biodefense conducts research on emerging pathogens and biological agents. They focus on diagnostics, host response, infection models, and antibiotic resistance, using DNA microarrays and molecular beacons for early diagnosis of infections. The center collaborates with other institutions and has received funding from NIH for the Regional Biocontainment Laboratory.

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Biodefense Research: NJMS Center for Biodefense and Emerging Pathogens

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  1. Biodefense-related ResearchUMDNJ-New Jersey Medical School Nancy Connell, Ph.D. Director, UMDNJ Center for Biodefense Vice-chair for Research Department of Medicine

  2. MOU With NYC Newark: MMRS Renew MOU With NYC HHS funding (NJDoHSS) 2002, 2003 Emerging Pathogens 1999 DoD funding 2000 DoD funding 2001 Incident Support And Operational Planning (2002) Member:Domestic Preparedness Task Force - NJ WMD first- Responder training BT annex Univ. Hospital plan: State model NIH- Regional Center of Excellence in Biodefense UH-EMS Anthrax attacks “Public Health War College” 9-11 Center for Biodefense Mobilization of expertise MOU NJDoH INFORM ICPH (PHRI) HRSA Funding 2003 Regional Biocontainment Laboratory DoD funding 2002,2003

  3. Biological Agent Research Capacity in Newark • Center for Emerging and Re-emerging Pathogens (NJMS) • International Center • for Public Health • NJMS Microbiology • NJMS Nat’l TB Center • Public Health Research Inst

  4. Bacillus anthracis Yersinia pestis Burkholderia mallei Francisella tularensis Mycobacterium tuberculosis Hantaan virus Dengue virus Monkeypox Influenza virus SARS Biological agents

  5. Biological research areas • Diagnostics • DNA microarrays • Molecular beacons • Host response • Testing vaccine response (smallpox vaccine) • Infection models • Antibiotic resistance

  6. DNA microarrays • Infection by different organisms will turn on and off different patterns of genes in the host. • Can we determine these patterns and use them for early diagnosis of infection?

  7. uninfected vs virulent avirulent vs virulent 37 0 80 0 3 18 61 Total genes 44,561 uninfected vs virulent DNA microarray analysis of the host response to infection NJMS/NJDS: Gallagher Alland Raveche Schutzer CBD: Jessica Mann Paula Trzop Carolina Sofer CAG (PHRI) Pat Soteropoulos Anthony Galante NJIT Michael Recce Virginie Airis

  8. NIH Regional Center of Excellence in Biodefense and Emerging Pathogens • Northeast Biodefense Center(among 8 of 14 applied) • Consortium of 30 institutions: NY, NJ, CT • 200 + investigators (P.I., Ian Lipkin [Columbia]) • Commissioner Lacy: advisory board • 3 New Jersey investigators on executive committee • $45 million total award (5 yrs): $ 2 million to PHRI’sDavid Perlin as animal core director • Vaccines, therapeutics, diagnostics, training • Strong emphasis on global emerging infections (SARS, West Nile)

  9. NIH Regional Biocontainment Laboratory • Joint effort of NJMS and PHRI • $21 million award with 1/3 match by UMDNJ • 40,000 sq ft building adjacent to ICPH • University Heights Science Park • Jeannette Brummel, community liason • Brings total Newark BSL space to 22,000 sq ft

  10. Northeast Biodefense Center CAG (PHRI) Keck Center (Rutgers) PHRI The RBL: NJMS, PHRI Beacons (NJMS, PHRI) Arrays (NJMS) NIH biodefense research priorities

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