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Galileo

Galileo. Galileo. PROMED Galileo. Comparative gastro-intestinal toxicity of individual nonsteroidal anti-inflammatory drugs: a meta-analysis of 12 endoscopic studies involving 1725 rheumatic patients. L. PUCCETTI*, R. PUCCETTI**, N. SCORPINITI***, M.L. CIOMPI*. Galileo. PROMED Galileo.

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Galileo

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  1. Galileo

  2. Galileo PROMEDGalileo Comparative gastro-intestinal toxicity of individual nonsteroidal anti-inflammatory drugs: a meta-analysis of 12 endoscopic studies involving 1725 rheumatic patients. L. PUCCETTI*, R. PUCCETTI**, N. SCORPINITI***, M.L. CIOMPI*

  3. Galileo PROMEDGalileo OA or RA patients active treatments for at least 4 weeks standard doses native molecules detailed endoscopic data, both basal and final Inclusion criteria

  4. Galileo PROMEDGalileo CSLs, found by endoscopy, such as: ulcers (any size or complication) > 10 erosions or petechiae submucosal haemorrhages oozing or intraluminar bleeding Key outcome parameter

  5. Galileo PROMEDGalileo whole Italian population: 9.86 yolls people > 60 years old: 8.34 yolls people > 65 years old: 7,76 yolls YOLLS per fatal event

  6. Galileo PROMEDGalileo Cases considered in the meta-analysis

  7. Galileo Not survival (0.10) Surgery (0.167) Hospital Survival (0.033) (0.90) PROMEDGalileo Medical Uncomplicated (0.833) (0.839) CSL Ambulatory Not survival (0.967) Surgery (0.10) (%, variable) (0.167) Complicated Hospital NSAiD (0.161) (1.0) Survival (0.90) No CSL Medical (%, variable) (0.833) Fig. 1 Decision tree used to estimate the consequences of NSAiD-induced CSLs.

  8. Galileo Table III - CSLs, FEs and yolls estimated to be induced in 100.000 courses by any individual NSAiD. PROMEDGalileo Legenda: CSLs= clinicant significant lesions; FEs = fatal events;

  9. Galileo Table IV - Fatal events potentially avoidable in 100.000 courses by substituting a given NSAiD with the less toxic one on the g-i tract. PROMEDGalileo

  10. Galileo Table V - Years of life potentially saveable in 100.000 courses administered to patients > 60 years old, by substituting a given NSAiD with the others progressively safer on the g-i tract. PROMEDGalileo

  11. Galileo PROMEDGalileo NSAID-induced G-I toxicity decreases life expectancy Ketoprofen is the most toxic on the G-I tract Tenoxicam is the less toxic on the G-I tract No significant differences among the other NSAIDs Different G-I toxicity reflects relevant differences in terms of costs and YOLLS CONLCUSIONS

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