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Cell-cell adhesion occurs through morphological structures and CAMs

Cell-cell adhesion occurs through morphological structures and CAMs. Cell adhesion is a dynamic Process that plays an important role in embryo development. Cell-cell adhesion is tissue-specific. Molecular structure of Cadherins. 1. Cadherin was identified via

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Cell-cell adhesion occurs through morphological structures and CAMs

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  1. Cell-cell adhesion occurs through morphological structures and CAMs

  2. Cell adhesion is a dynamic Process that plays an important role in embryo development

  3. Cell-cell adhesion is tissue-specific

  4. Molecular structure of Cadherins 1. Cadherin was identified via monoclonal antibody generation and in vitro aggregation assays 2. E-cadherin was named also as uvomorulin

  5. Cadherin binds each other via homophilic binding

  6. Mode of cadherin interaction

  7. Mode of cadherin interaction

  8. Expression of cadherin is dynamically controlled during embryogenesis

  9. Catenins are adaptor proteins that bind cadherin to actin cytoskeleton

  10. Binding sites for classical cadherin

  11. b-catenin occurs both at cell adhesion site and within nucleus

  12. Phosphorylated b-catenin is degraded through ubiquitination pathway

  13. Nuclear b-catenin enhances cell proliferation

  14. Mutated APC complex promotes entry of b-catenin into nucleus and enhances cell proliferation

  15. Inappropriate expression of b-catenin induces cell cycle progression in intestine

  16. b-catenin binds diverse proteins

  17. Molecular structure of N-CAM 1.N-CAM comprises 5 Ig-like extracellular domains 2. Mode of binding is via heterophilic interaction

  18. Molecular structure of Selectin

  19. Classification of cell junctions

  20. Components of junctional complex

  21. General structure of anchoring junctions

  22. Intermediate junction (adhesion belt)

  23. E-cadherin constitutes the core of intermediate junction

  24. Desmosome

  25. Desmosome

  26. Molecular components of desmosomes

  27. Desmosomes connect epithelial cells as a whole

  28. Tight junctions prevent passage of extracellular material into intracellular space

  29. Molecular components of hemidesmsomes

  30. Cell adhesion needs cytoskeleton

  31. Gap junctions are made up of connexons with a 2nm intracellular gap

  32. Each connexon is made of 6 subunits (connexin) and controls passage of molecules with MW < 1000 Da

  33. Cell-matrix interaction

  34. Extracellular matrix reorganizes cytoskeleton of transformed cells

  35. Integrin functions as linking molecule for ECM and cytoskeleton

  36. Colocalization of integrin and actin cytoskeleton

  37. Molecular structure of Integrin

  38. Focal adhesion Focal complex Focal contacts

  39. Rac dependent formation of focal complex

  40. Dentritic network model of actin assembly

  41. Molecular constitutents of focal complex

  42. How focal complex is assembled into focal contact ? ? ?

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