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Superficial mycoses

Superficial mycoses. Superficial cutaneous fungal infections involve skin and its appendages like hair and nails Causative fungi colonize only cornified layer of epidermis or supra-follicular portions of hair and do not penetrate into deeper anatomical sites.

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Superficial mycoses

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  1. Superficial mycoses

  2. Superficial cutaneous fungal infections involve skin and its appendages like hair and nails • Causative fungi colonize only cornified layer of epidermis or supra-follicular portions of hair and do not penetrate into deeper anatomical sites

  3. Tissue damage is very low, and immune response is also low • Patients invariably tend to neglect such types of infections and seek medical attention usually for cosmetic reasons and not because of any discomfort

  4. Surface infections: Pityriasisversicolor Tineanigra White and black Piedra • Cutaneous infections Dermatophytoses Candidiasis

  5. Dermatophytes

  6. Dermatophytes are a group of closely related filamentous fungi that infect only superficial keratinised tissues- the skin, hair and nails • Dermatophytoses : cutaneous fungal infections affecting skin, hair and nails • Dermatomycosis : diseases of skin caused by fungi other than dermatophytes

  7. Dermatophytes are hyaline septate molds with more than hundred species • They are divided into 3 genera depending on the morphological characteristics: • Trichophyton • Microsporum • Epidermophyton

  8. Ecological classification of dermatophytes:

  9. Clinical manifestations are mostly due to immune response of the host to the invading fungus • Exoenzymes are released by the fungi which help in invasion and utilization of host tissue by the fungus

  10. Pathogenesis: • Dermatophytes grow only within dead, keratinized tissue • The fungal cells produce keratinolytic proteases • Fungal metabolic products diffuse into the epidermis to cause erythema, vesicles, pustules along with pruritis • Hyphae become old, break into arthrospores which are shed off in time • This is partially responsible for the central clearing in ringworm type of lesions

  11. The hyphal tips growing down within hair shaft reach the edges of living keratinizing cells and form Adamson’s fringe • The infective process ceases and healing occurs when the balance of fungus and host is tilted in favour of host • Clinical features result from combination of keratin destruction and inflammatory response generated by host

  12. Clinical features • Ringworm or tinea depending on the anatomical site involved • Term ‘tinea’ is derived from latin word meaning ‘worm’ or ‘moth’ • Inflammation is seen maximum at the advancing margins leaving central area with some clearing

  13. Tineacapitis: • Infection of shaft of scalp hairs • Kerion: severely painful inflammatory reaction producing raised, circumscribed boggy mass on scalp, with suppurative lesions on the scalp, discharging pus • Favus: condition with cup-like crusts around infected follicles, may lead to patchy alopecia and scarring

  14. Ectothrix infection: hyphae produce arthrospores arranged as mosaic sheath around hair or as chains on surface of hair shaft, • cuticle of hair remains intact

  15. Endothrix infection: hyphae form arthrospores within hair shaft, which is severely weakened • cuticle of hair is usually destroyed

  16. Tineacorporis: disease of the skin over body, result from extension of infection from scalp, groin or beard • Erythematous scaly lesions, annular, sharply marginated plaques with raised border which may be single or multiple

  17. Tineagladiotorum: is an emerging infection in wrestlers • It is as a result of direct skin- to-skin contact • Lesions are on arms, trunk or head and neck • Tineafaciei: infection of non-bearded regions of face • Tineacruris: infection of groin and mostly present in men using tight-fitting garments • Seen in perineum, scrotum, perianal area

  18. Tineabarbae: infection of beard and moustache areas of face, erythematous patches on face which show scaling, fragile lusterless hairs

  19. Tineamanuum: infection of skin of palmar aspect of hands • Diffuse hyperkeratosis of palms and fingers • Tineapedis: infection of plantar aspect of foot, toes and interdigital web spaces • Warmth and moisture produced by shoes are key factors in infection • Seen in people wearing shoes for long hours • Popularly known as Athlete’s foot • Scaling, fissuring, erythema with itching or burning sensation • Small vesicles rupture and discharge thin fluid

  20. Tineaunguium: infection of nail plates • Begins with the free edge of nail plate or along lateral nail fold and may continue until entire nail plate or nail bed is infected • Onychomycosis: fungal infection of nail- dermatophytes or non-dermatophytes

  21. Id reaction: Dermatophytid reaction: • Secondary eruption occuring in sensitisedtinea patients because of ciculation of allergenic products from primary site of infection • This may develop following the initiation of oral antifungal therapy • Frequently seen in patients with absence of delayed reaction to dermatophytic antigen i.e. trichophytin

  22. Laboratory diagnosis • Specimen collected: • Skin scrapings, nail clippings, plucked infected hair, pus etc • Selection of infected hair for examination by Wood’s lamp • Microscopy: • 10% KOH wet mount examination: fungus appears as branching hyaline mycelia, with arthrospores • Examination of hair for endothrix, ectothrix • Examination of nails, skin

  23. Fungal culture: • On Sabouraud’s dextrose agar • Species identification by culture examination- macroscopic appearance and microscopic appearance • Lactophenol cotton blue stain (LP mount) for microscopic examination • Growth is slow and colonies appear only in 1-3 weeks

  24. Trichophyton: Colonies are powdery, velvety or waxy with pigmentation characteristic of species • Microconidia are abundant and arranged in clusters along the hyphae or borne on conidiophores • Macroconidia are relatively scanty

  25. Microsporum: • Colonies are cottony, velvety white to brown pigmentation • Microconidia are relatively scanty • Macroconidiaare predominant, large, multicellular, spindle-shaped

  26. Epidermophyton: • Colonies are powdery and greenish yellow (khaki-coloured), with raised and folded centre • Microconidia are absent • Macroconidiaare multi-cellular, pear-shaped and arranged in clusters

  27. Skin infection Hair infection Nail infection • Trichophyton • Microsporum • Epidermophyton Hair infection Skin infection Skin infection Nail infection

  28. Treatment: • Topical antifungal agents are effective for skin infections • Oral griseofulvin is the drug of choice

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