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Biology of the B lymphocyte

Biology of the B lymphocyte. Figure 7.1 Differentiation pathway of B lymphocytes. Dashed lines on the pre-B cell indicate surrogate light chains. The two lines associated with the cell surface heavy chain represent the molecules Iga and Igb. Overview of B cell development.

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Biology of the B lymphocyte

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  1. Biology of the B lymphocyte

  2. Figure 7.1 Differentiation pathway of B lymphocytes. Dashed lines on the pre-B cell indicate surrogate light chains. The two lines associated with the cell surface heavy chain represent the molecules Iga and Igb.

  3. Overview of B cell development

  4. Bone marrow stromal cells are required for maturation of progenitor B cells into precursor B cells

  5. Figure 7.2 A: The pre-B-cell receptor (pre-BCR). B: The B-cell receptor (BCR). The heavy chain of the pre-BCR is a m chain; the heavy chain of the BCR may be a m, d, g, a, or e chain. The immunoreceptor tyrosine-based activation motif (ITAM, discussed later in this chapter) is depicted as a rectangle in the Iga and Igb polypeptides.

  6. Figure 7.3 Interaction of the immature B cell with self-antigens.

  7. B cell activation by TD antigen

  8. Figure 7.4 Important molecules expressed on the surface membrane of the mature B cell.

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