1 / 31

Role of Vaccination in Control of BVDV

Role of Vaccination in Control of BVDV. 2004 NCBA Cattleman’s College. Dan Grooms DVM, Michigan State University, College of Veterinary Medicine. Goal For The Day. Type of BVDV vaccines available Role of vaccines in BVDV control. Seventh Edition of Compendium of Veterinary Products

goro
Download Presentation

Role of Vaccination in Control of BVDV

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Role of Vaccination in Control of BVDV 2004 NCBA Cattleman’s College Dan Grooms DVM, Michigan State University, College of Veterinary Medicine

  2. Goal For The Day • Type of BVDV vaccines available • Role of vaccines in BVDV control

  3. Seventh Edition of Compendium of Veterinary Products 147 BVDV vaccine combinations available

  4. Types of BVDV Vaccines • Killed or inactivated • Modified-live or attenuated

  5. Advantages Generally safer Dead virus Pregnant cows Handling More stable Can use over time if handled correctly Disadvantages Protection not as good Duration Breadth Immune response different than live virus More expensive Triangle 10 ds = $11.85 Pyramid 10 ds = $ 9.69 Killed BVDV Vaccines

  6. Advantages Generally better protection Duration Breadth Immune response more closely mimics natural exposure Cheaper Express 10 ds = $ 8.59 Elite 10 ds = $10.65 Disadvantages Safety Live replicating organism Potential for transmission Potential for mutation Potential of fetal infection Handling Susceptible to inactivation Must use once mixed Modified-Live BVDV Vaccines

  7. 2 1a 1b Type of Virus in The Vaccine 1 a & b 2 Continuum of Antigenicity

  8. Chart of MLV BVDV Vaccines Not complete

  9. Chart of Killed BVDV Vaccines Not complete

  10. Location Exposure Time of Year Type of Vaccine Contraindications Considerations IN/SQ/IM Management Economics Animal Use

  11. Pigs Sheep Mucosal Disease Deer? Thrombocytopenia Acute Infection Normal Acute Death Poor Performance BRD Diarrhea Immunosuppression Immunosuppression Fetal Infection Subclinical Infection Persistent Infection Abortions Normal Congenital Defects “Weak Calf” Syndrome

  12. Pigs Sheep Mucosal Disease Deer? Thrombocytopenia Acute Infection Normal Acute Death Poor Performance BRD Diarrhea Immunosuppression Immunosuppression Fetal Infection Subclinical Infection Persistent Infection Abortions Normal Congenital Defects “Weak Calf” Syndrome

  13. Fetal Protection Against BVDV * Protected/Challenged

  14. Van Campen JVDI 2000;12:263

  15. BVDV Vaccination and Fetal Protection Vaccination for BVDV is not 100%!! Combine with biosecurity and PI management Point #1

  16. 2 1a 1b Antigenic Diversity Does a vaccine containing type 1 BVDV protect against a type 2 BVDV challenge (or vice versa)???????

  17. Control Control 100% PI’s MLV Type 1 Vaccine Day 75 Gestation Type 1 Challenge Type 2 Challenge 10 Normal 2 PI’s 11 Normal 8 PI’s 83% Protection 58% Protection Cortese et al AJVR 1998;59:1409 Brock et al Vet Thera 2001;2:354

  18. BVDV Vaccination and Fetal Protection Vaccination for BVDV is not 100%!! Combine with biosecurity and PI management Point #1 It is desirable to provide broad protection against antigenic diversity of BVDV Point #2

  19. Timing of BVDV Vaccine to Maximize Fetal Protection

  20. Infertility Normal/Abnormal Seropositive Congenital Defects Immunotolerance-PI’s Abortion EED 0 1 2 3 4 5 6 7 8 9 Month Time line of BVDV effects on Bovine Reproduction

  21. BVDV Vaccination and Fetal Protection Vaccination for BVDV is not 100%!! Combine with biosecurity and PI management Point #1 It is desirable to provide broad protection against antigenic diversity of BVDV Point #2 Timing of vaccination should maximize immunity in early pregnancy Point #3

  22. Pigs Sheep Mucosal Disease Deer? Thrombocytopenia Acute Infection Normal Acute Death Poor Performance BRD Diarrhea Immunosuppression Immunosuppression Fetal Infection Subclinical Infection Persistent Infection Abortions Normal Congenital Defects “Weak Calf” Syndrome

  23. Protection Against Acute BVDV Disease • Most experimental studies show good protection against acute disease. • Most studies show protection when vaccine virus and challenge virus are different (type 1 vaccine, type 2 challenge). • No real good large scale field trials looking at vaccine efficacy.

  24. Performance Of Feedlot Cattle Exposed To Animals Persistently Infected With Bovine Viral Diarrhea Virus D.L. Grooms and K.V. Brock

  25. Vaccine Effect on Feedlot Calf Performance

  26. Vaccine Effect on Feedlot Calf Performance $6

  27. BVDV Vaccination and Acute Infection Protection requirements may not be as stringent as for fetal protection …reasonable cross protection Point #1

  28. Vaccine Effect on Feedlot Calf Performance

  29. BVDV Vaccination and Acute Infection Protection requirements may not be as stringent as for fetal protection …reasonable cross protection Point #1 Vaccination for BVDV is not 100%!! Combine with biosecurity and PI management Point #2

  30. Control and Prevention of BVDV • Biosecurity • Seek and Destroy PI’s • Vaccination Program • Strategic in Timing • Broad Protection Against Virus Diversity

  31. Dan Grooms DVM Michigan State University College of Veterinary Medicine 517-432-1494 groomsd@cvm.msu.edu

More Related