Organic Chemistry III

1. Organic Chemistry III Dr. Ralph C. Gatrone Department of Chemistry and Physics Virginia State University

2. Organic Chemistry IIICHEM320-01-071 • Office Hours • T: 11 – 12 and W: 8 - 12 • By appointment (524-5762) • Office: HM239Nb • Email: rgatrone@vsu.edu

3. Course Description • Principles of organic chemistry with emphasis on reaction mechanisms, synthetic methodology, and the interpretation of spectral data.

4. TENTATIVE SCHEDULE • Isolation and Purification of Organic Compounds • Extraction; Recrystallization; Melting and Boiling Points; Distillation; Sublimation; Thin Layer Chromatography; Gas-Liquid Chromatography; Liquid Chromatography • Mass Spectrometry • Infrared Spectroscopy • Nuclear Magnetic Resonance Spectroscopy • Description of Organic Reactions – Review • Writing Reaction Mechanisms • Primary and secondary isotope effects • Linear Free-Energy • The Hammett Equation • Molecular orbital theory • Woodward Hoffmann Theory and Frontier Molecular Orbital Theory

5. Text Materials • Required Text • Advanced Organic Chemistry – Miller • Organic Chemistry – A Biological Approach – McMurry • Available from Dr. Gatrone • Techniques in Organic Chemistry – Mohrig • Principles of Instrumental Analysis – Skoog • Organic Chemistry – Hoffman • Advanced Organic Chemistry – Carey • Organic Synthesis – Fuhrhop • Classics in Total Synthesis – Nicolaou

6. Evaluation • Homework Assignments – 100 points • Exam 1 – 100 points • Exam 2 – 100 Points • Final Exam – 200 Points • Total = 500 points • A = 450 or more points • B = 400 – 449 points • C = 350 – 399 points • D = 275 – 349 points • F = 274 or fewer points