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Featured Article :. High Concentrations of AGE-LDL and Oxidized LDL in Circulating Immune Complexes Are Associated With Progression of Retinopathy in Type 1 Diabetes.

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Featured Article :

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  1. Featured Article: High Concentrations of AGE-LDL and Oxidized LDL in Circulating Immune Complexes Are Associated With Progression of Retinopathy in Type 1 Diabetes Maria F. Lopes-Virella, M.D., Ph.D., Nathaniel L. Baker, M.S., Kelly J. Hunt, Ph.D., Timothy J. Lyons, M.D., Alicia J. Jenkins, M.D., Gabriel Virella, M.D., Ph.D., The DCCT/EDIC Study Group* Diabetes Care Volume 35: 1333-1340 June, 2012

  2. Study Objectives • To determine whether immunocomplexes (ICs) containing advanced glycation end product –LDL (AGE-LDL) and oxidized LDL (oxLDL) contribute to the development of retinopathy over a 16-year period in subjects with type 1 diabetes Lopes-Virella M et al. Diabetes Care 2012;35:1333-1340

  3. Study Design • 517 participants in the DCCT/EDIC cohort • Levels of AGE-LDL and oxLDL in ICs measured • Retinopathy assessed by stereoscopic fundus photography • Cox proportional hazards models used to assess effect of AGE-LDL-ICs and oxLDL-ICs on retinopathy progression Lopes-Virella M et al. Diabetes Care 2012;35:1333-1340

  4. Lopes-Virella M et al. Diabetes Care 2012;35:1333-1340

  5. Lopes-Virella M et al. Diabetes Care 2012;35:1333-1340

  6. Lopes-Virella M et al. Diabetes Care 2012;35:1333-1340

  7. Conclusions • Increased levels of AGE-LDL and oxLDL in ICs are associated with increased risk for progression to advanced retinopathy in patients with type 1 diabetes • Suggests that the antibody response to modified LDL plays a significant role in retinopathy progression Lopes-Virella M et al. Diabetes Care 2012;35:1333-1340

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