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Supplemental Data - Figure 1.

Supplemental Data - Figure 1.

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Supplemental Data - Figure 1.

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  1. Supplemental Data - Figure 1. Excel macro output generated using the cut-offs in Table 4 to identify those samples requiring further investigation. Samples 1-16 are from normal Hb infants. Transfused infant sample (high A(ßT1):F ratio and increased ßT1-3 peptide abundances with lower HbF abundance). Premature infant (low A(ßT1):F ratio, with lower ßT1-3 peptides relative to HbF abundance). ß-thalassaemia (low ßT1-3 peptide abundances), HbE/ ß-thalassaemia (low ßT3 abundance). The HbSS, HbS/C and HbS/ß-thalassaemia cases all had S:A ratios ≥2.1 and the sample ID is flagged with a dashed line around the box. The ß-thalassaemia and E/ß-thalassaemia cases do not have raised S:A ratios ≥2.1 or an S:A ratio ≥0.1 but <2.1 in conjunction with an additional raised variant peptide ratio and therefore are not flagged with a dashed line.

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