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Enzymes Make It Happen!. Dairy. Dairy. Curds. Curdling is clumping of milk proteins Cottage cheese Separates milk into curds (solid) and whey (liquid) Little Miss Muffett Most basic form of cheese. How & Why Cheese ?. M ilk stored in stomach bags quickly curdled
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Curds • Curdling is clumping of milk proteins • Cottage cheese • Separates milk into curds (solid) and whey (liquid) • Little Miss Muffett • Most basic form of cheese
How & Why Cheese ? • Milk stored in stomach bags quickly curdled • Curds lasted a long time; are edibleand nutritious • Caused by an enzyme called Rennin
Enzymes act as catalysts • What is a catalyst? • What is an enzyme? • Josh says enzymes cause reactions to take place. Is this true?
Enzymes • What is a enzyme functionally? A molecule that makes a reaction more likely to happen. • What is an enzyme physically? A protein or RNA molecule that catalyzes reactions. • Josh says enzymes cause reactions to take place. Is this true? No! Enzymes only help reactions take place.
An Abstract View of what Enzymes do • Substrate: molecule being acted on. • Active site: where substrate interacts with enzyme • Product: molecule produced after enzyme action.
An Abstract View of what Enzymes do – Part 2 • Makes reaction more likely to happen • Enzyme breaks a bond in substrate • Substrate can now bond with reactant • There are other enzyme behaviors!
Movement and Meetings • How do molecules move? • How enzyme, substrate and other reacting molecules find each other? • What type movement patterns could make interactions possibe? • Ideas? • Talk about it in your groups for a few minutes
StarLogo TNG • Used to make Models of Movement and Meetings • You will use StarLogo to make a simulation that • Models biological processes
Inhibitors Competitive Inhibition • Inhibitors ___________?_______________. • Competitive inhibition: ________?_______.
Inhibitors Competitive Inhibition • Inhibitors prevent enzymes from binding. • Competitive inhibition: The inhibitor binds in the activesite, preventing the substrate from binding.
Inhibitors Allosteric Inhibition • Inhibitors prevent enzymes from binding. • Allosteric inhibition: _______?__________.
Inhibitors Allosteric Inhibition • Inhibitors prevent enzymes from binding. • Allosteric inhibition: The inhibitor binds in the inhibitor site, changing the conformation of the active site.
Reactant Concentrations • How does the concentration of substrate affect the reaction rate? • How does the concentration of enzyme affect the reaction rate? • How does the concentration of inhibitors affect the reaction rate?