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Cell Signaling

This introductory cell signaling course explores the mechanics of signal transduction pathways and their impact on cellular responses. Students will evaluate, design skits, and predict pathway changes under different conditions.

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Cell Signaling

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  1. Cell Signaling

  2. Tidbit Overview Course: Introductory Cell Molecular Biology. Unit title: Cell Signaling – The Original Social Networking. Class enrollment: 25 – 250 freshman or sophomore Student experience: Near the end of the term. Within the signal transduction unit Homework and pre-class assessment to encourage participation: Review cell signaling (notes and previous class content) and turn in written responses to LOC/HOC questions.

  3. Sensing the Rainbow: Demonstration of signal detection and transduction • Nose pinched • Chew skittle • Let go of nose • What happens?

  4. Sensing the Rainbow: Demonstration of signal detection and transduction • Nose pinched • Chew skittle • Let go of nose • What happens?

  5. Olfaction detection is based on GPCRs -

  6. Activity and Outcomes • Activity: Dramatize a signal transduction pathway • Outcome: The students will be able to model a hypothetical signal transduction pathway to elicit a specific cellular response

  7. What we want you to know and do • Evaluate the G protein coupled receptor pathway • Identify key components of cell signaling pathways • Design a skit to illustrate the mechanics of the pathway • Predict how the pathway would change under different conditions

  8. Timing of Tidbit Min Activity 0-2: Introduction and demonstration 2-7: In your NASI group evaluate your returned homework (total 8 groups) 7-21: Two groups merge, to plan performance (total 4 groups) 21-26: Combine 2 planning groups; perform/critique (total 2 groups)

  9. 5 Min: • In your NASI groups look at your returned homework handout. • Evaluate this piece of work using the following rubric:

  10. 13 Min: • Two groups merge (now 4 groups in total) • Create dramatization to illustrate pathway • Suggestion – divide the group into performers and a director

  11. 5 Min: Dramatime! Again pair with another group Within pair, one group performs, the other critiques (using Rubric provided) the performance

  12. Wild Card 1Beta blocker – examples Inderal or Lopressor • Blocks the binding site for epinephrine on the beta-receptor • What is the effect on your signaling pathway?

  13. Wild Card 2: Caffeine Inhibits the phosphodiesterase that breaks down cAMP. How does this affect your signaling pathway?

  14. Wild Card 3 - Anthrax One toxin in Anthrax (EF) - Increases cAMP levels Another (LF) triggers the degradation of the kinase further downstream

  15. Student Outcomes • Were you able to evaluate and construct a complete signaling pathway based on other students’ homework? • Were you able to create an accurate skit that showed you learned the pathway? • Did you see how altering the pathway affected signal transduction? • Did acting out this cellular process deepen your understanding of cell biology?

  16. Professor Outcomes • Did the students achieve the learning objective? • Modeling a hypothetical signal transduction pathway that elicited a cellular response? • Make notes in Teacher Diary of the successes and problems with executing the activity.

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