Endocrine System

1. Endocrine System Chapter 39

2. Endocrine System • A system of glands that secrete hormones into the blood that regulate growth, development and metabolic processes.

3.  The Endocrine Glands Section 39-1 Hypothalamus The hypothalamus makes hormones that control the pituitary gland. In addition, it makes hormones that are stored in the pituitary gland. Pineal gland The pineal gland releases melatonin, which is involved in rhythmic activities, such as daily sleep-wake cycles. Thyroid The thyroid produces thyroxine, which regulates metabolism. Pituitary gland The pituitary gland produces hormones that regulate many of the other endocrine glands. Pancreas The pancreas produces insulin and glucagon, which regulate the level of glucose in the blood. Parathyroid glands These four glands release parathyroid hormone, which regulate the level of calcium in the blood. Ovary The ovaries produce estrogen and progesterone. Estrogen is required for the development of secondary sex characteristics and for the development of eggs. Progesterone prepares the uterus for a fertilized egg. Thymus During childhood, the thymus releases thymosin, which stimulates Tcell development. Testis The testes produce testosterone, which is responsible for sperm production and the development of male secondary sex characteristics Adrenal glands The adrenal glands release epinephrine and nonepinephrine, which help the body deal with stress.

4. Hormones • Hormones– chemical messengers that travel to remote target tissues. • Produce “slow” responses of long duration. • Hormones only affect target tissues that have the correct receptor to fit the hormone.

5. Hormone Action Section 39-1 Nonsteroid hormone (first messenger) Steroid Hormone Receptor Target cell membrane Target cell membrane Receptor cAMP (second messenger) Hormone-receptor complex Altered cellular function Nucleus Enzyme activities DNA Altered cellular function Protein synthesis Nucleus Cytoplasm Cytoplasm mRNA

6. Negative Feedback • Hormone levels in the blood are regulated by a negative feedback mechanism. • Hormones secreted into the blood bring about a change. When the change occurs, secretion of the hormone stops. • Ex: The pancreas secretes insulin to lower blood sugar levels and glucagon to raise blood sugar levels. Secretion of these hormones stops when sugar levels are correct. • Diabetics cannot produce enough insulin to maintain correct sugar levels.

7. Actions of Insulin and Glucagon Section 39-2 Pancreas releases insulin into the blood Body cells absorb glucose Blood glucose level increases Blood glucose level decreases Liver converts excess glucose to glycogen for storage Homeostasis: Normal blood glucose level Blood glucose level increases Blood glucose level decreases Liver converts glycogen to glucose Pancreas releases glucagon into blood

8. The Reproductive System Chapter 39

9. Reproduction • A life process necessary for the survival of a species, but not an individual…

10. The Male Reproductive System • The testes produce the male sex cell sperm through the process of meiosis. • Sperm are haploid (23 chromosomes). • The testes also produce the hormone testosterone. • Testosterone aids in sperm production and is responsible for the development of secondary sex characteristics.

11. The Male Reproductive System Section 39-3

12. The Female Reproductive System • The ovaries produce the female sex cell eggs through the process of meiosis. • Eggs are haploid (23 chromosomes). • The ovaries also produce the hormones estrogen and progesterone. • Estrogen aids in egg development and is responsible for the formation of secondary sex characteristics. Progesterone prepares the uterus for implantation by a fertilized egg.

13. The Female Reproductive System Section 39-3

14. The Menstrual Cycle • Beginning with puberty, the female reproductive system begins a periodic cycle of events regulated by hormones from the pituitary and ovaries. • This is known as the menstrual cycle. • This cycle prepares the uterus each month for the advent of pregnancy, when a fertilized egg will implant itself in the uterine wall. • If this does not occur, the uterine lining is shed out the vagina. This is called menstruation.

15. The Menstrual Cycle Section 39-3

16. Fertilization and Development • Fertilization occurs in the Fallopian tube (oviduct). • A sperm unites with the egg to produce a diploid zygote (46 chromosomes). • The zygote undergoes a series of mitotic cell divisions without growth in size (cleavage) on its way to the uterus. • Approximately 7 days later the hollow ball of cells (blastocyst) implants itself in the uterine wall. • Development occurs in the uterus (womb).

17. Fallopian tube Zygote 4 cells 2 cells Morula Blastocyst Uterine wall Ovary Fertilization and Implantation Section 39-4 Day 2 Day 3 Day 1 Day 4 Fertilization Day 0 Day 7 Implantation of blastocyst Egg released by ovary

18. Development • After implantation the cells begin to differentiate. • Tissue from both the mother and embryo form the placenta – a temporary organ that will nourish the developing baby. • Throughout the next nine months the developing baby obtains nutrients and gets rid of wastes through its connection to the placenta, the umbilical cord. • Nutrients and wastes pass between the blood of the mother and baby by diffusion.

19. The Placenta Section 39-4

20. Birth • At the end of nine months hormone changes produce a series of contractions in the uterus known as labor. • The protective membrane surrounding the baby (amnion) ruptures releasing fluid (“water breaks”). • Birth is imminent. Contractions stretch the cervix to a diameter of about 10 cm and the baby is delivered head first (usually). • Contractions close off the umbilical cord near the baby. The cord is cut, and eventually falls off leaving a scar (belly button). • Soon after, a second series of contractions force the placenta out of the womb (after birth).