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Cell Communications

Cell Communications. Chapter 5.5-5.6. Types of communication. Differentiate between the following: Paracrine Endocrine Autocrine. Steps to communicate. Step 1: Multiple Receptor types. Cytoplasmic receptor proteins Membrane bound receptor proteins G-protein linked receptors

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Cell Communications

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  1. Cell Communications Chapter 5.5-5.6

  2. Types of communication • Differentiate between the following: • Paracrine • Endocrine • Autocrine

  3. Steps to communicate

  4. Step 1: Multiple Receptor types • Cytoplasmic receptor proteins • Membrane bound receptor proteins • G-protein linked receptors • Receptor tyrosine kinases • Ligand gated ion channels • Be able to compare and contrast each of the above. • Know what type of signals activate each • Provide examples of each

  5. Cytoplasmic receptors How do they work? What is different about the chemistry of the signals?

  6. G-Protein Linked receptor How does it work? What is different about the GDP to GTP transition as compared to the GTP to GDP transition?

  7. Receptor tyrosine kinases How does it work?

  8. Ligand gated ion channels How does it work?

  9. Step 2: Transduction Second messengers Phosphorylation cascades

  10. Second messengers What are they? Examples? Advantages to using them?

  11. Second messengers

  12. Phosphorylation cascade What are they? Advantages?

  13. Regulating signal transduction • How does a cell regulate this process? • While the number of “steps” creates increased regulation, it also creates increased risk of malfunction. Explain.

  14. Step 3: Response Likely responses to a signal???

  15. Specificity of the Signal

  16. Putting it all together

  17. Examples to be familiar with How does caffeine interfere with a signaling pathway to keep us “perky”? - adenosine receptor antagonist - inhibitor of cAMPphosphodiesterase Be able to explain the epinephrine pathway from signal to response!

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