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The 3 articles presentation

The 3 articles presentation. Fahimeh nezhadmoghadam. “Missed” Mild Cognitive Impairment: High False-Negative Error Rate Based on Conventional Diagnostic Criteria. Journal Name : Journal of Alzheimer's disease Journal Impact Factor : 3.920

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The 3 articles presentation

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  1. The 3 articles presentation Fahimehnezhadmoghadam

  2. “Missed” Mild Cognitive Impairment: High False-Negative Error Rate Based on Conventional Diagnostic Criteria • Journal Name : Journal of Alzheimer's disease • Journal Impact Factor : 3.920 • Research Group :Department of Psychiatry, University of California San Diego • Principal Author : Emily Edmonds, Total citations 472 , h-index 11 Lisa Delano-Wood, Total citations 2001 , h-index 27 Amy Jak, Total citations 2544 , h-index 30 Douglas R. Galasko, Total citations 41623 , h-index 94 David P. Salmon , Total citations 29216 , h-index 80

  3. Abstract • Mild cognitive impairment (MCI) is diagnosed : • subjective complaints • screening measures • clinical judgment • a single memory score. • This method is highly susceptible to false-positive diagnostic errors. Aims : • To examine whether the criteria also lead to "false-negative" errors by diagnostically reclassifying 520 participants using novel actuarial neuropsychological criteria. • Results revealed a false-negative error rate of 7.1%. • The impact of "missed" cases of MCI has direct relevance to clinical practice, research studies, and clinical trials of prodromal Alzheimer's disease.

  4. Diagram showing the flow of progression to MCI and AD for the false-negative and true-negative groups

  5. Demographic characteristics and neuropsychological performance for the false-negative and true-negative groups.

  6. Subtypes based on neuropsychological performance predict incident dementia: Findings from the Rush Memory and Aging Project • Journal Name : Journal of Alzheimer's disease • Journal Impact Factor : 3.920 • Research Group :Albert Einstein College of Medicine • Principal Author : Andrea R. Zammit , Citation 79, h- index 6,  Graciela Muniz-Terrera , Total citations 1085 , h-index 12 Mindy J.Katz , Total citations 6505 , h-index 41 Ali Ezzati, Total citations 245 , h-index 9

  7. Aims : • To identify the association of natural subgroups based on neuropsychological performance in the MAP cohort with incident dementia and compare them with the associations identified in the EAS (Einstein Aging Study). • MAP : the Rush Memory and Aging Project. Methods : • MAP is a community-dwelling cohort of older adults living in the northeastern Illinois, Chicago. •  Applied Latent class models to baseline scores of 10 neuropsychological measures across 1,662 dementia-free MAP participants. • Compared results to prior findings from the EAS.

  8. Results : • LCA resulted in a 5-class model: • Mixed-Domain Impairment (n = 71, 4.3%), • Memory-specific-Impairment (n = 274, 16.5%), • Average (n = 767, 46.1%), • Frontal Impairment (n = 222, 13.4%), • a class of Superior Cognition (n = 328, 19.7%).

  9. Cumulative Hazards of Dementia for each of the classes.

  10. Cumulative hazards of Alzheimer’s dementia for each of the classes

  11. Statistically-Derived Subtypes and Associations with Cerebrospinal Fluid and Genetic Biomarkers in Mild Cognitive Impairment: A Latent Profile Analysis • Journal Name : Journal of the International Neuropsychological Society • Journal Impact Factor : 2.777 • Research Group :Veterans Affairs San Diego Healthcare System • Principal Author : Joel S. Eppig, Total Citation 231, h- index 8,  Emily Edmons, Total citations 472 , h-index 11 Laura Campbell, Total citations 3286 , h-index 23 Mark Sanderson, Total citations 3365 , h-index 30 Lisa Delano-Wood, Total citations 2001 , h-index 27

  12. Aims: • To examine whether unique neuropsychological MCI profiles could be identified using latent profile analysis (LPA) • Then, to investigate cerebrospinal fluid (CSF) biomarkers, genotype, and longitudinal clinical outcomes between the empirically-derived classes. Methods : • 806 participants received a comprehensive neuropsychological battery assessing visuoconstructional ability, language, attention/executive function, and episodic memory. • To adjust Test scores for demographic characteristics using standardized regression coefficients based on “robust” normal control performance (n=260).

  13. Methods: • used calculated z-scores in the LPA. • At the end, CSF-derived biomarkers, genotype, and longitudinal clinical outcome were evaluated between the LPA-derived MCI classes. Results: • Final Class Counts and Proportions for Most Likely Class Membership of 3-Class LPA.

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