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DNA Replication http://www.youtube.com/watch?v=hfZ8o9D1tus (YouTube) Transcription & Translation http://molo.concord.org/database/activities/273.html (FLASH) What makes a firefly glow? PBS: The Secret of Life (YouTube) Translation
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DNA Replication • http://www.youtube.com/watch?v=hfZ8o9D1tus (YouTube) • Transcription & Translation • http://molo.concord.org/database/activities/273.html (FLASH) • What makes a firefly glow? • PBS: The Secret of Life (YouTube) • Translation • http://www.abdn.ac.uk/~clt011/flash/samples/protein.swf (FLASH)
DNA is a Nucleic Acidhttp://ghr.nlm.nih.gov/dynamicImages/understandGenetics/basics/chromosome_structure.jpghttp://www.phoenix5.org/glossary/graphics/CellChromoDNAGene.gif
Allnucleotidesconsist of3 parts:--- 5 C sugar,N base&Phosphate grouphttp://fig.cox.miami.edu/~cmallery/150/chemistry/sf3x6.jpg
Onlycomplementary baseswillpair together(i.e., form abond)http://fig.cox.miami.edu/~cmallery/150/gene/c16x6base-pairs.jpghttp://fig.cox.miami.edu/~cmallery/150/gene/16x5bc.jpg
DNAforms aDouble Helixhttp://test3-sftt.terc.edu/units/genes/common_content/images/s01_helix-ladder_01.gifhttp://www.starsandseas.com/SAS_Images/SAS_Genetics_images/DNA_images/dnamodel_1.jpg
Why doesDNAneed to be in the form ofchromatinforreplicationto occur?http://www.eduvinet.de/mallig/bio/Repetito/Mitose1.html • This cell is in interphase. Notice the chromatin in the nucleus. • This cell is in prophase. The DNA has already replicated and now the chromatin is getting shorter (forming chromosomes).
DNA replicationissemi-conservativehttp://www.nicerweb.com/doc/class/bio100/Locked/media/ch14/DB14050.jpghttp://www.steve.gb.com/images/science/dna_replication_fork.png
DNA Replicationhttp://fig.cox.miami.edu/~cmallery/150/gene/c16x7copy-dna.jpg
DNAvs.RNAhttp://images.clinicaltools.com/images/gene/dna_versus_rna_reversed.jpgDNAvs.RNAhttp://images.clinicaltools.com/images/gene/dna_versus_rna_reversed.jpg
TRANSCRIPTION(DNARNA)http://www.brooklyn.cuny.edu/bc/ahp/BioInfo/graphics/Transcription.01.GIFhttp://fig.cox.miami.edu/~cmallery/150/gene/dogma.htmTRANSCRIPTION(DNARNA)http://www.brooklyn.cuny.edu/bc/ahp/BioInfo/graphics/Transcription.01.GIFhttp://fig.cox.miami.edu/~cmallery/150/gene/dogma.htm
CODONScodeforAmino Acidshttp://evolution.berkeley.edu/evosite/evo101/images/codon_GCA.gifhttp://coris.noaa.gov/glossary/codon_186.jpg
The Genetic Codehttp://fig.cox.miami.edu/~cmallery/150/gene/sf11x10.jpg
DNA mRNA Protein http://www.iir.suite.dk/IIR/15genes/images/15DNAToProt2.gif
TRANSLATION= the synthesis ofproteins(polypeptides)http://mandevillehigh.stpsb.org/2005site/teacher_sites/laura_decker/dna_and_rna_diagrams_files/image008.jpghttp://ghs.gresham.k12.or.us/science/ps/sci/ibbio/chem/nucleic/chpt15/tRNA.gif
tRNAscarryamino acidsto the proper location on themRNAstrand • Anticodonsare complementary tothecodonsof mRNA
The Central Dogma of Molecular Geneticshttp://www.anselm.edu/homepage/jpitocch/genbio/transcrtransl.JPG http://www.anselm.edu/homepage/jpitocch/genbio/codonsAA.JPG
http://library.thinkquest.org/C004535/protein_synthesis.html
Double-strandedDNA will unzip for TWO reasons… http://www.sidwell.edu/us/science/vlb98/projects/protein/smarks/dnarepvsprosynp.gif
GENE MUTATIONS–insertions,deletions&substitutions http://fajerpc.magnet.fsu.edu/Education/2010/Lectures/26_DNA_Transcription.htm
SICKLE-CELL ANEMIAhttp://www.anselm.edu/homepage/jpitocch/genbio/effectsofsickle.JPGhttp://healthgate.partners.org/images/si55551158.jpg
Sickle-Cell Anemia is the result of a substitution(point)mutation http://fajerpc.magnet.fsu.edu/Education/2010/Lectures/26_DNA_Transcription.htm
AaxAahttp://www.sciencemuseum.org.uk/exhibitions/genes/225.aspAaxAahttp://www.sciencemuseum.org.uk/exhibitions/genes/225.asp SICKLE-CELL ANEMIA
TAY-SACHS DISEASEhttp://lovequilts2005children.homestead.com/RachaeliF.htmlhttp://www.snof.org/maladies/tay.html Rachaeli F. Born: October 25, 2002 Illness: Tay-Sachs Disease (terminal)
PHENYLKETONURIA (PKU)http://www.newbornscreening.info/tools/GraphicsLib/phenylketonuria.jpg
CYSTIC FIBROSIS (CF)http://images.webmd.com/images/hw/media66/medical/hw/nr551844.jpghttp://www.cfgenetherapy.org.uk/images/phyisiotherapy.jpg
HUNTINGTON’S DISEASE (HD)http://www.curehd.org/ PLEASE HELP ME SAVE MY KIDS!!! My name is Robert Bishop. I am 43 years old and the father of five at-risk children (ages 18, 15, 12, 9, and 7). In 1998, I sold my computer software business to take up the cause of fund raising and public awareness for a terminal illness called Huntington's Disease (HD). Unless a cure is found, 2 or 3 of my children will tragically die from this disease. Each has a 50% chance of having inherited a defective gene from their first mother, Amy (who became symptomatic for HD in her mid-twenties).
AMNIOCENTESIShttp://amniocentesis.upmc.com/Images/Sub/ImageAmnio.jpgAMNIOCENTESIShttp://amniocentesis.upmc.com/Images/Sub/ImageAmnio.jpg
GENETIC ENGINEERINGhttp://floti.bell.ac.uk/mcgarvieg/Insulin.gif
CLONING http://www.vamr.org/img/scnt_flow.jpg http://static.howstuffworks.com/gif/cloning-sheep.gif