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F 2006 BIOC 3405

F 2006 BIOC 3405. 09-07-06. Amino Acids. Fundamental particle of proteins Put together into proteins indirectly aa + t-RNA + ATP  aminoacyl-tRNA + H 2 O aminoacyl-tRNA’s  proteins “Residues” – amino acid minus H 2 O. Fischer projection. Change in charge with change in pH. pK a.

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F 2006 BIOC 3405

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  1. F 2006 BIOC 3405 09-07-06

  2. Amino Acids • Fundamental particle of proteins • Put together into proteins indirectly • aa + t-RNA + ATP  aminoacyl-tRNA + H2O • aminoacyl-tRNA’s  proteins • “Residues” – amino acid minus H2O

  3. Fischer projection

  4. Change in charge with change in pH pKa charge ~1 charge ~2 pH units pH

  5. In listing start at N terminal (N terminal on the left).

  6. Proteins • Peptide chains with n > ~50 or M > ~5000 • May have multiple chains (multisubunit) • Components chains called oligomers • Identical – protomers • Non identical – “hetero-” e.g., heterodimer.

  7. Avg mass of residue 125 110 108 110 90 90 112 112 105 108 113 110 111

  8. Amino Acid composition • Amino acid analysis • 6M HCl 24 h 40 deg • Changes Asn, Gln to Asp, Glu. Listed as Asx and Glx • Destroys Trp • Base hydrolysis, other procedures for complete resolution

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