Collaborative Islet Transplant Registry (CITR) 2010 Annual Report Exhibits

1. Collaborative Islet Transplant Registry (CITR) 2010 Annual Report Exhibits Prepared by:CITR Coordinating CenterThe EMMES CorporationRockville, MDSponsored by:National Institute of Diabetes & Digestive & Kidney DiseasesNational Institutes of HealthJuvenile Diabetes Research FoundationDatafile Closure: March 21, 2011

2. Collaborative Islet Transplant Registry 2010 • Follow-up time after initial infusion for each recipient. Top: islet after kidney (N=65), bottom: islet alone (N=347). Yellow: insulin independence; green: insulin-using with graft function (70% average reduction in daily insulin use from baseline); black: no islet function; gray: missing data. Red marks indicate re-infusions. Pie charts show percent of all follow-up time with insulin independence.

3. Chapter 1: Islet Transplant Activity Chapter 2: Recipient and Donor Characteristics Chapter 3: Pancreas Procurement, Islet Processing, and Infusion Characteristics Chapter 4: Immunosuppression and Other Medications Chapter 5: Graft Function Chapter 6: Liver, Kidney, Lipid, and PRA Effects Chapter 7: Adverse Events Chapter 8: Registry Data Quality Review CITR Coordinating Center CITR Committees Table of Contents

4. Chapter 1: Islet Transplant Activity

5. CITR Recipients, Infusions and Donors byNIDDK/JDRF Sites and by ITA/IAK/SIKConsented, Registered and First Infused in 1999-2009

6. Cumulative Enrollment in CITR

7. Islet Transplant Centers Reporting Data to CITRParticipating North American Centers 1999-2009 A - CITR Centers with at least one islet allograft infusion procedure conducted in 2008C - CITR Centers with no islet allograft infusions in 2008D - CITR Coordinating Center

8. Islet Transplant Centers Reporting Data to CITRParticipating European Centers 1999-2009 A - CITR Centers with at least one islet allograft infusion procedure conducted in 2008 B - CITR Centers with data reports pending

9. Islet Transplant Centers Reporting Data to CITRParticipating Australian Centers 1999-2009 A - CITR Centers with at least one islet allograft infusion procedure conducted in 2008 C - CITR Centers with no islet allograft infusions in 2008

10. Number of Islet Transplantation Centers Performing Islet Allograftsper Year and Number with Data Entered in CITR Database All North American Islet Transplant Centers 1999-2009

11. Total Number of Islet Allograft Recipients, Recipients at CITR-Participating Centers, and Recipients with Detailed Data Reported to CITR by Year of First Islet Allograft InfusionAllograft recipients at North American Islet Transplant Centers 1999-2009

12. Total Number of Islet Allograft Recipients and Recipients with Detailed Data Reported to CITR by Year of First Islet Allograft InfusionCITR-Participating European and Australian JDRF Centers1999-2009

13. Total Number of Islet Allograft Infusion Procedures Performed andNumber with Data Reported to CITRCITR-Participating North American Islet Transplant Centers 1999-2009

14. Total Number of Islet Allograft Infusion Procedures Performed and Number with Data Reported to CITRCITR-Participating European and Australian JDRF Centers1999-2009

15. Islet Allograft Infusions by Infusion Sequence Number and YearCITR-Participating North American and JDRF Centers, 1999-2009

16. Islet Allograft Recipients by Total Infusions to Date and YearCITR-Participating North American and JDRF Centers, 1999-2009

17. Total Number of Islet Allograft Infusions Per Recipient:CITR-Participating North American and JDRF Centers, 1999-2009

18. Total Number of Deceased Donors per Islet Allograft InfusionCITR-Participating North American and JDRF Centers, 1999-2009

19. Allograft Islet Alone and Islet After Kidney and Simultaneous Islet-Kidney Autograft RecipientsParticipating North American and JDRF Centers, 1999-2009

20. Chapter 2: Recipient and Donor Characteristics

21. Recipient Demographics

22. Recipient Demographics (continued)

23. Recipient Characteristics at First Infusion

24. Recipient Diabetes Characteristics and Medical History

25. Recipient Diabetes Characteristics and Medical History (continued)

26. Recipient Diabetes Characteristics and Medical History (continued)

27. Recipient Diabetes Characteristics and Medical History (continued)

28. Recipient Autoantibodies and Sensitization at First Infusion

29. Recipient Autoantibodies and Sensitization at First Infusion (continued)

30. Recipient Infectious Disease Testing at First Infusion

31. Recipient Characteristics Prior to First Infusion by Total Number of Infusions Received

32. Recipient Baseline Autoantibodies by Total Infusions Received

33. Recipient Laboratory Values at First Infusion

34. Donor Demographics

35. Donor Characteristics

36. Donor Characteristics (continued)

37. Donor Hospitalization

38. Donor Hospitalization (continued)

39. Donor Hospitalization (continued)

40. Donor Serology

41. Donor Laboratory Data

42. Organ Crossmatch Results

43. Chapter 3: Pancreas Procurement, Islet processing and Infusion Characteristics

44. Islet Processing Summary

45. Islet Processing Summary (continued)

46. Pancreas Digestion Combinations Involving Thermolysin/Pulmozyme

47. Final Islet Preparation Microbiology (Positive)

48. Cold Ischemia Information

49. Islet Product Characteristics

50. Islet Product Characteristics by Infusion Sequence