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1. CHRONIC SPECIFIC BONE INFECTION DR.MARWAN ZAMZAMI,ABOS
2. CHRONIC SPECIFIC BONE INFECTION TUBERCULOSIS
BRUCELLOSIS
FUNGAL
SYPHILIS
3. TUBERCULOSIS THE BASIC MICROSCOPIC LESION; THE TUBERCLE
FIRST DISCOVERED BY THE FRENCH PHYSICIAN LAENNEC (1781-1826) WHO DIED AT THE AGE OF 45 BY TB
4. TUBERCULOSIS ESTIMATED 30 MILLION TB PATIENTS WORLD WIDE.
1 -3 % (300 000 1000 000) HAVE SKELETAL INVOLVEMENT
5. TUBERCULOSIS OF BONES AND JOINTS TB Bacilli lived in symbiosis with mankind since time immemorial. Recorded in ancient Egyptian mummies
Still common in developing countries
6. REDUCED INCIDENCE OF TB DUE TO: IMPROVED LIVING STANDARDS; SANITATION, HYGIENE, NUTRITION
B.C.G. VACCINE (80% PROTECTION)
7. TUBERCULOSIS BACILLI
8. TUBERCULOSIS
10. BLOOD SUPPLY AND STAGNATION
LOCAL TRAUMA; HAEMATOMA?
LOCAL STEROIDS ?
11. TB PATHOLOGY Secondary to other primary TB lesions (Pulm., GL, Renal, LN)
Route of spread:
HAEMATOGENOUS ****
DIRECT (much less)
* bone to joint
* soft tissue to bone
THE PRIMARY LESION
QUIESCENT
ACTIVE: (Apparent, Latent)
12. TB PATHOLOGY INFLAMMATION HYPEREMIA - OSTEOPENIA
TB FOLLICLES (TUBERCLE):
LYPHOCYTE MONOCYTES
ENDOTHELIAL CELLS
LANGHANS GIANT CELLS
COALESCE
CASEATION LATER
GRANULATION TISSUE
BONE DISTRUCTION
SINUSES
13. TB Follicle
14. TB PATHOLOGY (JOINTS) SYNOVIAL SWELLING
GRANULATION TISSUE
PERIPHERAL ARTICULAR DESTRUCTION
NO PROTEOLYTIC ENZYMES
CENTRAL ARTICULAR WEIGHT-BEARING AREA PRESERVED
RICE BODIES
FIBRIN & ARTICULAR CARTILAGE
INCREASED BLOOD SUPPLY
OSTEOPENIA
16. CLINICAL PICTURE AGE
INSIDIOUS ONSET
MONO ARTICULAR
OTHER LESIONS
FAMILY HISTORY CONTACT
GROUPS AT RISK
17. SYMPTOMS & SIGNS CONSTITUTIONAL LOW GRADE FEVER
ANOREXIA
WEIGHT LOSS
NIGHT SWEATING
TACHYCARDIA
ANEMIA
18. SYMPTOMS & SIGNSLOCAL Symptoms :
PAIN
NIGHT CRIES
SWELLING
STIFFNESS
ULTERED FUNCTION
Signs :
WASTING
SYNOVIAL SWELLING
TENDERNESS
WARM
STIFFNESS
LIMPING
19. INVESTIGATIONS LEUCOPENIA LYMPHOCYTOSIS
ANEMIA
RAISED ESR
MANTOUX POSITIVE
NOT IN:
MILIARY TB / RECENTLY VACCINATED/
ON STEROIDS / REDUCED IMMUNITY / FEVER
20. RADIOLOGY CHEST X-RAY : ALL PATIENTS
JOINTS: PHEMISTERS TRIAD:
1. PERIARTIC. OSTEOPENIA
2. REDUCED JOINT SPACE
3. PERIPH. OSSEOUS EROSIONS
BONES: 1. DESTRUCTION
2. SEQUESTRATION
3. ABSCESS FORMATION
21. RADIOLOGY BONE SCAN: MONO ARTICULAR
CF: RHEUMATOID ARTHRITIS
CALLIUM SCAN INFECTION
CT SCAN MORPHOLOGY
MRI MORPHOLOGY
34. DIAGNOSTIC ASPIRATION:
AFB POSITIVE
HISTOLOGICAL
CULTURE
36. TB SPINE (POTTS DISEASE)PERCIVAL POTT 1779 SECONDARY TO OTHER PRIMARY
HEMATOLOGICAL
20% OTHER VISCERA
12% OTHER BONES/JOINTS
TWO ADJACENT VERTEBRAE SOMETIMES MORE THAN ONE
SKIP LESIONS IN 7%
37. TB SPINESURGICAL PATHOLOGY FIRST THREE DECADES
THORACO-LUMBAR
CENTRAL SPINE
SPARKS POSTERIOR ELEMENTS
SPREADEDS UP/DOWN ANT./POST. LONG. LIGS.
LESIONS COALESCE COLLAPSE
KYPHUS FORMATION
38. TB SPINESURGICAL PATHOLOGY PARA VERTEBRAL ABSCESS
CERVICAL : RETROPHARALYGEAL
THORACIC : P.V. & ALONG RIBS
LUMBAR : PSOAS ABSCESS
POSTERIOR:LUMBAR TRIANGLE
ANTERIOR: ILIAC FOSSA
BELOW ING. LIG.
NEUROLOGICAL COMPLICATION
MORE IN THORACIC (NARROWEST CANAL)
40. TB SPINECLINICAL FEATURES GENERAL: INSIDIOUS ONSET
CONSTITUTIONAL
LOCAL: PAIN FIRST INDICATION
LOCAL REFERRED
STIFFNESS SPASM
WEAKNESS NEUROLOGICAL
41. SIGNS OF TB SPINE MUSCLE SPASM
KHPHUS GIBBOUS
TENDERNESS
STIFFNESS
PARA VERTEBRAL ABSCESS
NEUROLOGICAL WEAKNESS
PARAPLEGIA
43. TB SPINERADIOLOGICAL FEATURES DISC NOT INVOLVED PRIMARILY
NARROWING OF DISC SPACE
BONE DESTRUCTION
USUALLY TWO ADJACENT VERTEBRAE
MAY SHOW SKIP LESIONS
PARA VERTEBRAL ABSCESS
KHYPUS
CT/MYELOGRAM/MRI IN PARAPLEGIA
57. PARAPLEGIA IN TB SPINE IN 10-30% OF TB SPINE
MORE IN THORACIC REGION
PRESSURE ON CORD ANTERO LATERAL
MOTOR EARLIER THAN SENSORY
SIGNS: UPPER MOTOR NEURON
MAY START BY CORD SHOCK
REMARKABLE ABILITY TO RECOVER
58. PARAPLEGIA IN TB SPINECAUSED BY EXTRADURAL PRESSURE GRANULATION TISSUE
PRESSURE OF ABSCESS & CASEATON
SEQUESTRUM
PATHOLOGICAL FRACTURE/DISLOC.
SEVERE KYPHUS
INFLAMMATION: TOXIC EDEMA
VASCULAR
59. MANAGEMENT OF TB SPINE USUALLY CONSERVATIVE
GENERAL
SPECIFIC
REST
IMMOBILISE
CHEMOTHERAPY SURGICAL
DIAGNOSE
ASPIRATION
DRAIN ABSCESS
DEBRIDE
DECOMPRESS
ANTERIOR
ANTERO-LATERAL
STABILISE FUSION
60. MOST CASES OF TB SPINE RESPOND VERY WELL TO CONSERVATIVE TREATMENT INCLUDING THOSE WITH PARAPLEGIA
THE NEED FOR SURGICAL DECOMPRESSION OF THE CORD IS LIMITED
61. BRUCELLOSIS MILK AND MILK PRODUCTS
BACK PAIN AND STIFFNESS
MUSCLE SPASM
FEVER MILD
SACRO-ILIAC JOINT
LESS DESTRUCTIVE OF TB
BRUCELLA TITRE
ANTIBIOTICS
e.g. SEPTRIN - OXYTETRACYCLINE
62. SYPHILIS SPIROCHETE
TREPONEMA PALLIDUM
CONGENITAL SYPHILIS COMMONEST
CHRONIC OSTEOCHONDRITIS
PERIOSTEITIS
OSTEITIS
TIBIA LESABRE TIBIA
63. FUNGAL INFECTION CHRONIC VERY LOW GRADE
FEET FARMERS THORNS Madura Foot
SLOW DESTRUCTION
SINUSES GRANULES
SECONDARY BACTERIAL INFECTION
RESISTANT TO CHEMOTHERAPY
NEEDS SURGICAL DEBRIDEMENT
IF ADVANCED MAY NEED AMPUTATION