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Single Nucleotide Polymorphism SNP

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Single Nucleotide Polymorphism SNP

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    1. Single Nucleotide Polymorphism (SNP) ACTCGAGCTA ACTCGCGCTA

    10. Monogenic Versus Polygenic Disease Monogenic: One base change = disease. Relatively easy to detect and analyze. Polygenic: A set of base changes affect the probability of disease. Subtle – hard to detect and analysis

    12. Structure Modeling High throughput >40% sequence ID Fixed backbone Graph based search for side chain arrangements Identify unreliable regions

    13. Retinol (Vitamin A) Binding Protein Missense Mutation: Gly-75 to Asp-75 Disease: Vitamin A Deficiency

    14. Aldehyde Dehydrogenase 10 Missense Mutation: Leu-106 to Arg-106 Disease: Sjogren-Larsson Syndrome

    15. Distribution of the Effects of Missense cSNPs on Protein Molecular Function for the SNP-Disease Set

    23. Steady State Abundance

    25. Relationship of Experimental Total PAH Enzyme Activity (%) and the Protein Level (%)

    29. The Structure of a TCR Heterodimer

    30. Effect of Missense SNPs in the Framework Regions (FR) of TCR Vßs

    35. http://www.SNPS3D.org

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