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BY Dr. Mirza Shahed Baig

Narcotic analgesic Drugs. BY Dr. Mirza Shahed Baig. WHAT IS PAIN. Pain is a crucial aspect of the body’s defense mechanisms Pain “is a part of a rapid warning relay instruction the motor neurons of the central nervous system to minimize detected physical harm ”.

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BY Dr. Mirza Shahed Baig

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  1. Narcotic analgesic Drugs BY Dr. Mirza Shahed Baig

  2. WHAT IS PAIN Pain is a crucial aspect of the body’s defense mechanisms Pain “is a part of a rapid warning relay instruction the motor neurons of the central nervous system to minimize detected physical harm ”

  3. Some of the most common causes of pain include: • headache • postsurgical pain • post-trauma pain • lower back pain • cancer pain • arthritis pain • neurogenic pain (pain caused by nerve damage) • psychogenic pain (pain that isn’t caused by disease, injury, or nerve damage)

  4. Degree of Pain

  5. Centrally Acting Analgesics

  6. Morphine and its derivatives

  7. Sources of Morphines

  8. Poppy plant

  9. Natural Opium Alkaloids

  10. Morphine Side effects

  11. Morphine binding to its Receptors

  12. MORPHINE MOA

  13. Metabolism of Morphine

  14. Metabolism of Morphine

  15. Chemistry of Morphine

  16. Chemistry of Morphine • Early Changes on Morphine Nucleus (Before 1929) • Modification carried out by Small, Eddy and Co-workers ( After 1929) • Modification carried out by Eisleb and Shaumann (1938) • Modification carried out by Grewes (After 1946)

  17. Early Changes on Morphine Nucleus (Before 1929)

  18. Early Changes on Morphine Nucleus (Before 1929)

  19. Early Changes on Morphine Nucleus (Before 1929)

  20. Modification carried out by Small, Eddy and Co-workers ( After 1929)

  21. Modification in Aromatic Ring

  22. Modification in Aromatic Ring

  23. Modification in Aromatic Ring

  24. Modification in Alicyclic Ring

  25. Modification in Alicyclic Ring

  26. Modification in Alicyclic Ring

  27. Modification in Alicyclic Ring

  28. Modification in Alicyclic Ring

  29. Modification in Tetrahydrofuran Ring

  30. Modification at tert. N atom.

  31. Modification at tert. N atom.

  32. Modification carried out by Eisleb and Shaumann (1938)

  33. Modification carried out by Eisleb and Shaumann (1938) • Meperidine Series • Bemidones Series • Prodines Series • Fentanyl Series • Methadone Series

  34. Modification carried out by Eisleb and Shaumann (1938)

  35. Meperidine, Bemidones, Prodines

  36. Fentanyl Series

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