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LEUKEMIA

LEUKEMIA. Definition leukemia. Leukemia – it is tumor , which erise from bloodforming cells and primary demages bone marrow. Classification of leucosis. Acute leucosis myeloid lymphoid Chronical leucosis myeloid lymphoid. Acute myeloid leucosis. Undifferentiated

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LEUKEMIA

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  1. LEUKEMIA

  2. Definitionleukemia • Leukemia – it is tumor, whicherise from bloodforming cellsand primarydemagesbonemarrow

  3. Classification of leucosis • Acute leucosis • myeloid • lymphoid • Chronicalleucosis • myeloid • lymphoid

  4. Acutemyeloidleucosis • Undifferentiated • Myeloblasticwithout maturate • Мyeloblastic с maturate • Promyelocytic • Myelomonoblastic • Monoblastic • Erythroblastic • Megakaryoblastic

  5. Histochemicalcriteries of acuteleucosis differentiation • 1. Peroxidase reaction • 2. Acidicphosphatase reaction • 3. Unspecific esterase reaction • 4. Lipid reaction • 5. Compound carbohydrates reaction

  6. Reaction ofmyeloblastesand other cells ofneutrophiliclineofperoxidase

  7. Reactionof monoblastesofα-naphtylacetateesterase

  8. Reaction ofmyeloblastesandmonoblastesof acidicphosphatase

  9. Reactionwith blacksudanof lipids

  10. Acidic sulfurated mucopolysaccharides reaction

  11. Acuteundifferentiatedleucosis - blood

  12. Acuteundifferentiated leucosis – b. marrow

  13. Acuteundifferentiated leucosis– b. marrow. Аtypical cells

  14. Acutemyeloblastic – b. marrow. Initialstage. Granularmyeloblast. Aur’s stab

  15. Acutemyeloblastosis– b. marrowТotalmyeloblasticmetaplasia

  16. Acutemyeloblasticleucosis – blood. Peroxidase reaction

  17. Acutemyeloblasticleucosis – b. marrow. Peroxidasereaction

  18. Acutemyeloblastosis – b. marrowOf the left – peroxidasereaction (2)Of the right – Aur’s stab (2)

  19. Acute myelomonoblastisis – b. marrow. Esterase reaction

  20. Acute erythroblastosis – b. marrowErythroblastdouble sproutsharpMyeloblast withAur’s stab

  21. Acutemegakaryoblasticleucosis – b. marrow

  22. Acutelymphoidleucosis • Leycosis of generaltype • Т-lymphoblastic • В-lymphoblastic

  23. Acutelymphoblasticleucosis – blood. Lymphocytecandlymphoblastes

  24. Acute lymphoblastic leucosis - blood

  25. Acute В-lymphoblastosis – b. marrow Bigvacuolized lymphoblastes

  26. Acute lymphoblasticleucosis – b. marrow

  27. Acutelymphoblasticleucosis –b. marrow. Initialstage

  28. Acutelymphoblastosis – b. marrow Тоtal lymphoblasticmetaplasia

  29. Chronical myeloidleucosis • Myelocytic • Monocytic • Eosinophilic • Erythroblastic • Megakaryocytic

  30. Chronicalmyelocyticleucosis – blood. Chronicalphase

  31. Chronicalmyeloleucosis – bloodStage of crisis of blasticcells

  32. Chronicalmyelocyticleucosis– blood. Stages of maturate ofneutrophils

  33. Chronicalmyeloleucosis – blood. Rejuvenation ofcellular staff

  34. Chronicalmyeloleucosis – b. marrow. Unfoldedstage

  35. Chronicalmyeloleucosis – b. marrow Stage ofcrisis ofblasticcells

  36. Chronicalmyelocyticleucosiswitheosinophilic – b. marrow

  37. Chronicalmyelocyticleucosis, eosinophilicvariant – b. marrow

  38. Chronicalmyeloleucosis, basophilic variantUnfolded stage

  39. Chronicalmyeloleucosis, basophilic variant – b. marrow. Stage ofcrisis ofblasticcells

  40. Chronical monocytic leucosis - blood

  41. Chronicallymphoid leucosis • В-lymphocytic • Т-lymphocytic (1,5 %) • Haircell

  42. Chronical В-cellslymphocyticleucosis - blood

  43. Chronical lympholeucosis – bloodNuclear Guprecht’s shadow

  44. Chronical lympholeucosis – b. marrow. Тоtallymphoidmetaplasia

  45. Chronical lympholeucosis – b. marrow. Тоtal lymphoidmetaplasia

  46. Chronicalhaircellleucosis - blood

  47. Chronicalhaircellleucosis - blood

  48. Haircell leucosis – blood. Acidic phosphatase reaction

  49. Mechanisms ofactivation of cellular oncogenes • Point mutation • Chromosomalaberration • Virustransduction • Insertious mutagenesis • Genesamplification

  50. Clinicalmanifestation ofleucosis • Metaplastic аnemia • Thrombocytopenia • Hemorrhagicsyndrome • Secondary immunodeficiency • Decrease ofresistance

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