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Genotypic Markers and HIV-1 Infection Disparities: CKR5 Variant in HIV-1 Positive and Risk-Negative Individuals

Explore genotypic markers linked to HIV-1 infection in comparison to high-risk HIV-1 negative individuals. Analysis includes CKR5 variant frequency disparities among different groups.

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Genotypic Markers and HIV-1 Infection Disparities: CKR5 Variant in HIV-1 Positive and Risk-Negative Individuals

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  1. HIV-1 Infection Vs HIV-1 Antibody-Negative Individuals And Genotypic Markers G-Test Jacinta Gaitor 2/15/02

  2. Rationale • Genomic DNA was screened by using 170 mapped polymorphic loci such as CD4, SCYAL, HLA-DQA1, TCRA, TCRB, and CKR5 to locate distortion of allele and geneotype frequency among HIV-1 positive vs high risked HIV-1 negative persons. • The significance of the geneotypic association between the HIV-1 positive and the high risked HIV-1 negative persons for each of the 170 loci is plotted in the following graph in physical order along each chromosome.

  3. A Graph Showing Genotypic markers 37 and HIV-1 infection [G test ]

  4. Conclusion • According to the data displayed in the graph, CKR5 show a significant distortion of genotype frequencies among the infected vs uninfected. • The normal or wild type (+) and CKR5 32 deletion in 738 homosexual male Caucasians show a significant difference of frequencies among HIV-1 infected and non infected individuals (p=200000). • The other loci (CD4, chemokine SCYAL, HLADQAL, TCRA,TCRB) on the other hand did not show such a significance.

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