Respiratory System

1. Respiratory System

2. Anatomy • The respiratory system starts from the nose, mouth, larynx, trachea, and the two lungs.

7. Within the lungs, the bronchi transport air with oxygen to the alveoli on inspiration and carry waste gases (e.g. carbon dioxide) away on expiration. • The acinus is the gas exchange unit of the lung and consists of branching respiratory bronchioles leading to clusters of alveoli. • Alveoli are tiny air sacs lined by flattened epithelial cells and covered in capillaries where gas exchanges occur

8. The alveoli and capillaries have extremely thin walls and come into very close contact (the alveolar capillary membrane) so gases can rapidly diffuse between them. There are approximately 300 million alveoli in each lung for gas exchange with a total surface area of 40-80 meter square.

9. The lungs has two blood supplies: 1) the bronchial arteries which arise from the aorta and supply oxygenated blood to the bronchial walls. 2) The pulmonary arteries which deliver deoxygenated blood to the capillaries surrounding the alveoli

11. Symptoms 1) Cough 2) Sputum production 3) Hemoptysis 4) Chest pain 5) Breathlessness

12. Symptoms 1 )Cough: Is a forced expulsive maneuver against an initially closed glottis. Causing characteristic sound. Can be acute (less than 3 weeks) or chronic (more then 8 weeks) The most common cause is acute viral infections of the upper airway system

13. Cough (features) Prolonged wheezy coughing: asthma, COPD. Feeble non-explosive (bovine): lung cancer (paralysis of vocal cords), neuromsucular disease causing respiratory muscle weakness Moist cough: secretions from infection, bronchiectasis, chronic bronchitis. Noctunral cough: asthma

14. Cough (causes) Chronic Gastroesophageal reflux disease (GERD) Asthma Post bronchial hyper-activity Rhinitis/sinusitis Cigarette smoking Drugs, ACE inhibitors Irritant dusts/fumes Lung tumors TB, Interstitial lung disease Bronchiectasis Acute: Viral respiratory tract infection Bronchitis Inhaled foreign body Inhalation of irritant dusts or fumes Pneumonia Acute extrinsic allergic alveolitis

15. Symptoms 2) sputum production • Amount • Colour • Taste or smell Examples: • COPD and chronic bronchitis: clear mucoid sputum if there is no infection • Lower respiratory tract infection: yellowish sputum (presence of live neutrophils) • Ashtma: yellowish sputum (eosinophils) • Bronchiectasis: large volumes of purulent sputum varying with posture • Pulmonary edema: watery sputum with a pink tinge

16. Symptoms 3) Hemoptysis Amount and appearance Duraion and frequency intermittent with recurrent infections over years: bronchiectasis Daily for a short periods (weeks) lung cancer, TB, abscess Single episodes with chest pain: pulmonary infarction.

17. Hemoptysis (causes) Infection: Bronchiectais, Tuberculosis, lung abscess, cystic fibrosis Tumours: Lung cancer, endobronchial metastasis, bronchial carcninoid. Vascular: Pulmonary infarction, arteriovenous malformation Vasculitis. Trauma Foreign body, iatrogenic

18. Hemoptysis (causes) Cardiac: Mitral Valve disease, acute left ventricular failure Hematological: Bleeding tendencies, anticoagulation

19. Symptoms 4) Chest pain: • Pleural chest pain • Chest wall pain • Mediastinal chest pain

20. Pleural chest pain • Is a sharp, stabbing pain and is intendified by inspiration or coughing caused by irritation of the parietal pleura. • Causes: Infection: pneumonia, bronchiectasis Pneumothorax Pulmonary infarction Connective tissue disease

21. Chest wall pain Causes: Chornic cough/breathlessness Muscular pain Rib fractures Bony metastasis Thoracis shingles (herpes zoster)

22. Mediastinal chest pain • Mediastinal chest pain is central, retrosternal and unrelated to respiration or cough. • Causes: Massive pulmonary embolism Acute myocardial infarction Aortic dissection Infection, irritant dusts Eshophagitis Mediastinitis Lymphadenopathy

23. Symptoms 5) Breathlessness • Shortness of breath, difficulty getting enough air. • Mode of onset • Minutes: pulmonary thromboembolism, pneumothorax, asthma, inhaled forein body • Hours to days: pneumonia, asthma. • Weeks to months: Anemia, Pleural effuion, neruomuscular disease. • Months to years: COPD, pulmonary fibrosis, TB, Heart failure.

24. Breathlessness Causes: Non cardio-respiratory: Anemia, Obesity, Psychogenic, Metabolic acidosis. Cardiac: Heart failure, mitral valve disease, pericarditis, pericaridal effusion Respiratory: Foreign body, Ashtma, COPD, Bronchiectasis, Lung cancer, pulomnary fibrosis, Pneumonia, Tuberculosis, pulmonary thromboembolism, pulmonary hypertension, pneumothorax, kyphoscholiosis. Neumuscular disease.

25. Physical Examination of the respiratory system General Examination Examination of the thorax Respiratory rate Breathing pattern Inspection Accessory muscles Stridor Palpation Hoarseness Cyanosis Blood pressure Skin Appearances Percussion Hands Neck Ascultation Shape of chest

26. Physical Examination of the respiratory system General Examination Examination of the thorax Respiratory rate

27. Respiratory rate Average: 14 breath per minute Normal 12-20 breth per minute Tachypnea: Increased ventilatory drive: Fever Acute asthma, COPD exacerbation Reduced ventilatory capacity: Pneumonia, Pulmonary edema, interstitial lung disease. Decreased respiratory rate

28. Physical Examination of the respiratory system General Examination Examination of the thorax Respiratory rate Breathing pattern

29. Breathing Patterns Periodic breathing (Cheyne-Stokes respiration) Hyperventilation Anxiety/emotional stress Metabolic acidosis (Kussmaul respiration)

30. Physical Examination of the respiratory system General Examination Examination of the thorax Respiratory rate Breathing pattern Accessory muscles Stridor

31. Stridor A harsh, rasping or croaking inspiratory noise resulting from turbulent airflow in the upper airway, aggravated by coughing. Should always be investigated, can be an emergency Causes foreign body or tumour partially occluding larynx, trachea or main bronchus epiglottitis Air way edema

32. Physical Examination of the respiratory system General Examination Examination of the thorax Respiratory rate Breathing pattern Accessory muscles Stridor Hoarseness Cyanosis

33. Cyanosis Is a bluish discoloration of the skin and mucous membranes Can be Central of Peripheral

34. Physical Examination of the respiratory system General Examination Examination of the thorax Respiratory rate Breathing pattern Accessory muscles Stridor Hoarseness Cyanosis Blood pressure Skin Appearances Hands

35. Hands • Clubbing (mild , moderate , gross ) Causes Familial Thoracic Non-Thoracic

37. Thoracic Lung cancer Mesothelioma Pleural fibroma Esophageal cancer Thymoma Atrial myxoma IPF Bronchiectasis, lung abscess Empyema CF Bacterial Endocarditis Cyanotic congenital heart disease Lung AV malformation Non Thoracic Liver cirrhosis Celiac disease Ulcerative colitis Crohn’s disease

38. Hands • Hypertrophic Pulmonary Osteoarthropathy (combination of clubbing and thickening of periosteum (connective tissue lining of the bones) and synovium) • Discoloration of the finger and nails • Tremor Fine tremor Coarse flapping tremor (asterixis)

39. Causes of flapping tremor Drugs barbiturates alcohol sodium valproate phenytoin carbamazaepine metoclopramide gabapentin ceftazidime opioids Respiratory failure/ CO2 retention Liver failure Renal failure Electrolyte disturbance Hypoglycemia Hypokalemia Hypomagensemia Wilson’s disease CNS Intracerebral hemorrhage subdural hematoma subarachnoid hemorrhage cerebral ischemia cerebral lymphoma

40. Physical Examination of the respiratory system General Examination Examination of the thorax Respiratory rate Breathing pattern Accessory muscles Stridor Hoarseness Cyanosis Blood pressure Skin Appearances Hands Neck

41. Neck JVP Neck Nodes

42. will see you soon next year Thank you