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NS1 Spring 2012. Lecture Order. 1) Receptor Trafficking Scaffolding Proteins at the PSD Signaling at the PSD. Trends Neurosci. 25:578, 2002. J. Neurosci. 19:6298, 1999. TINS 30:407, 2007. Control of NMDA surface expression through ER retention signal. Tubulin -> Microtubules
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NS1 Spring 2012 Lecture Order 1) Receptor Trafficking • Scaffolding Proteins at the PSD • Signaling at the PSD
Control of NMDA surface expression through ER retention signal
Tubulin -> Microtubules Actin -> Microfilaments <----Dynamic polymers <----Stable, only in neurons Neurofilaments -> NF-H, -M, -L Nature Reviews Neurscience 10:319, 2009
minus-end directed motor plus-end directed motor
Axoneme Assay plus-end directed motor: axoneme travels toward stable tail (-) minus-end directed motor: axoneme travels toward unstable head (+) Science 288:1796, 2000 Nature 347:780, 1990
http://mc11.mcri.ac.uk/wrongtrousers.html http://mc11.mcri.ac.uk/wrongtrousers.html
Microtubule Motility Assay (plus directed motor) YFP-KIF17
J. Neurosci. 23:131, 2003 http://www.pnas.org/cgi/content/full/222371099/DC1/1
Role of endocytosis of ion channels in regulating synaptic efficacy Science 285:215, 1999