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Presented by Terance Woodworth, M.S. at the September 9, 2003 meeting of the Anesthetic and Life Support Drugs Advisory Committee. ARCOS (sales at the retail level). Year-End Reports (distributions by dosage form manufacturers). IMS Health, IMS National Sales Perspectives ™
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Presented by Terance Woodworth, M.S. at the September 9, 2003 meeting of the Anesthetic and Life Support Drugs Advisory Committee
ARCOS (sales at the retail level) Year-End Reports (distributions by dosage form manufacturers) IMS Health, IMS National Sales Perspectives™ Extracted August 2003 Aggregate Production Quotas Estimates of U.S. ConsumptionMorphine (sale) (Kg)
Estimates of U.S. ConsumptionHydrocodone (sale) ARCOS (sales at the retail level) Year-End Reports (distributions by dosage form manufacturers) (Kg) IMS Health, IMS National Sales Perspectives™ Extracted August 2003 Aggregate Production Quotas
ARCOS (sales at the retail level) Year-End Reports (distributions by dosage form manufacturers) IMS Health, IMS National Sales Perspectives™ Extracted August 2003 ( total kg dispensed) Aggregate Production Quotas Estimates of U.S. ConsumptionOxycodone (sale) (Kg)
DAWN Mentions per 100,000 scripts Drug Abuse Warning Network IMS Health, National Prescription Audit Plus™ Consequences of Increased AvailabilityMorphine 1500 1200 900 (DAWN Emergency Department Mentions) Total Prescriptions Dispensed (per 100,000 pop.) 600 300 0
40,000 32,000 24,000 Total Prescriptions Dispensed (per 100,000 pop.) 16,000 8,000 0 DAWN Mentions per 100,000 scripts Drug Abuse Warning Network IMS Health, National Prescription Audit Plus™ Consequences of Increased AvailabilityHydrocodone (DAWN Emergency Department Mentions)
DAWN Mentions per 100,000 scripts Drug Abuse Warning Network IMS Health, National Prescription Audit Plus™ Consequences of Increased Availability Oxycodone 15,000 12,000 9,000 (DAWN Emergency Department Mentions) Total Prescriptions Dispensed (per 100,000 pop.) 6,000 3,000 0
DAWN Mentions per 100,000 scripts Linear Regression Trend line Attachment G Consequences of Increased Availability Morphine Hydrocodone Oxycodone
Attachment H State and Local Seizures of Opioids Source: National Forensic Laboratory Information System (NFLIS) 2001 2002 2000 2003 * *As of 8/27/03
Promotional Expenditures vs Dollar Sales IMS IPS and NSP Audits* $1,800,000 2002 Total Promotional Dollars $1,600,000 2002 Total Dollars Sales NSP $1,400,000 $1,200,000 $1,000,000 Dollars in Thousands $800,000 $600,000 $400,000 $200,000 $0 Actiq Avinza Kadian Duragesic MSContin OxyContin *IMS Health, IMS National Sales Perspectives™, Extracted August 2003 IMS Health, Integrated Promotional Services Audit™, Extracted August 2003