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UKOLN is supported by:

Open Science at Genome Scale Dr Liz Lyon, Director, UKOLN, University of Bath, UK Associate Director, UK Digital Curation Centre Survive or Thrive Workshop, Manchester, June 2010 . UKOLN is supported by:. This work is licensed under a Creative Commons Licence Attribution-ShareAlike 2.0.

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  1. Open Science at Genome Scale Dr Liz Lyon, Director, UKOLN, University of Bath, UK Associate Director, UK Digital Curation Centre Survive or Thrive Workshop, Manchester, June 2010 . UKOLN is supported by: This work is licensed under a Creative Commons LicenceAttribution-ShareAlike 2.0

  2. http://www.ukoln.ac.uk/ukoln/staff/e.j.lyon/publications.html#november-2009http://www.ukoln.ac.uk/ukoln/staff/e.j.lyon/publications.html#november-2009 • Open Science at Web-Scale • Scale, Complexity, Predictive Potential • Continuum of Openness • Citizen Science • Credentials, Incentives, Rewards • Institutional Readiness & Response • Data Informatics Capacity & Capability • Consultation: • Write-To-Reply • Keynote Presentations: • eResearch Australasia Nov 2009 • CNI, Baltimore April 2010 • http://www.ukoln.ac.uk/ukoln/staff/e.j.lyon/presentations.html

  3. $1000 genome in <15 minutes ....by 2013? ...Next next generation technology race to market

  4. ...data deluge challenges.... • Large-scale data storage that is: • Cost-effective (rent on-demand) • Secure (privacy and IPR) • Robust and resilient • Low entry barrier / ease-of-use • Has data-handling / transfer / analysis capability • Move sequencing out of genome centres • “....analyse an entire human genome in a single day sitting with a laptop at your local Starbucks.” ...cloud services?

  5. Clients in the cloud

  6. The “new” genome informatics ecosystem The case for cloud computing in genome informatics. Lincoln D Stein, May 2010

  7. “Data sets are becoming the new instruments of science”

  8. Post-genome decade Human genomes: >24 published & almost 200 unpublished

  9. “P4 medicine : Predictive, Personalised, Preventive, Participatory.”Leroy Hood – Institute for Systems Biology ...“medicine is going to become an information science”... Image from Scientific American

  10. P4 medicine • Each patient’s genome sequenced • Your genome is basis of your medical record • New method to anonymise medical records for genomics research at Vanderbilt Univ (April ‘10) • New predictive models of health and disease • Personalised treatments focus on preventative therapies Genome scale network biology Genomic data as a commodity

  11. They have shared their data….

  12. Share my data?

  13. Sage Bionetworks : Integrative genomics Open data in the Sage Commons repository Human and mouse: clinical and genetics data Develop predictive models of disease: liver / breast / colon cancer, diabetes, obesity Crowd-sourced effort : global scope Stephen Friend

  14. Participatory medicine : Empowering the patient... Sage Congress San Francisco April 2010

  15. Calls for action, new metrics

  16. How to cite large-scale predictive network models? • Incentivise: get credit • Attribution granularity • Multiple data sources & standards • Linked data approach • Workflow integration • Curate the data......

  17. Human Genome printed http://www.flickr.com/photos/johnjobby/2252981353/sizes/l/ Discuss.... • Scaleabledata infrastructure? • Personal genomics - share your data? • Transform 21stC medicine / bioscience? • Credit & attribution for data and models?

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