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REGULACE TVORBY ERYTROPOETINU

REGULACE TVORBY ERYTROPOETINU. Denisa Chadimová, 9.kruh 2011/2012. ERYTROPOETIN. Vztah Hb , erytropoetinu a erytropoezy. NEDOSTATEK EPO. DOSTATEK EPO. Transportní kapacita kyslíku. Hb. Počet erytrocytů. =. =. =. H Y P O XIE. HYPOXIE. Peritubulární buňka kortexu ledvin.

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REGULACE TVORBY ERYTROPOETINU

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  1. REGULACE TVORBY ERYTROPOETINU Denisa Chadimová, 9.kruh 2011/2012

  2. ERYTROPOETIN

  3. Vztah Hb, erytropoetinu a erytropoezy NEDOSTATEK EPO DOSTATEK EPO Transportní kapacita kyslíku Hb Počet erytrocytů = = = HYPOXIE

  4. HYPOXIE Peritubulární buňka kortexu ledvin HIF-1α–transkripční faktor indukovaný hypoxií (hypoxia-induciblefactor 1, alphasubunit) HIF-1β- aryl hydrocarbon receptor nucleartranslocator P300/CBP – komponenty transkripčního komplexu HRE – responzivní element (hypoxia – responsive element) HRE TRANSKRIPCE GENU ERYTROPOETIN

  5. NORMOXIE VHL – vonHippel-Lindau PHD – HIF-prolyl-hydroxykázy Ub - Ubiquitin oxidace Peritubulární buňka kortexu ledvin Ubikvitinizace degradace proteazom

  6. ZDROJE • http://en.wikipedia.org/wiki/Hypoxia_inducible_factors • http://www.wikiskripta.eu/index.php/Erytropoetin • http://www.remedia.cz/Clanky/Prehledy-nazory-diskuse/Molekularni-farmakologie-latek-stimulujicich-erytropoezu/6-F-iw.magarticle.aspx

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