1 / 20

ARV use as prevention tool is not a new concept

ARV use as prevention tool is not a new concept. Prevention of vertical transmission – 1991 Post-Exposure Prophylaxis - 1998 TasP Modeling for San Francisco – 2000 British Columbia “community viral load - 2008 Model to Eliminate HIV in South Africa – 2009.

katen
Download Presentation

ARV use as prevention tool is not a new concept

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. ARV use as prevention tool is not a new concept Prevention of vertical transmission – 1991 Post-Exposure Prophylaxis - 1998 TasP Modeling for San Francisco – 2000 British Columbia “community viral load - 2008 Model to Eliminate HIV in South Africa – 2009

  2. HPTN 052 – The study is stopped 4 years ahead of schedule 1763 sero-discordant couples 28 new infections – 27 were in the untreated group 96% reduction in transmission in the treated group 17 cases of extrapulmonary TB in the non-treated group and 3 cases in the group receiving early treatment (above 250 CD4 cells) Evidence that treating earlier prevents transmission AND is better for patients

  3. New Prevention Interventions Caprisa 004 KZN , South Africa CAPRISA 004 study found a 39% lower HIV infection rate in women using 1% Tenofovir gel Tenofovir gel provided 51% protection against herpes simplex virus type 2 or HSV-2 IPrex 11 sites in six countries (2 in Lima, Peru, one site in Iquitos, Peru, one site in Guayaquil, Ecuador, one site in Boston and one site in San Francisco in the United States, one site in Cape Town, South Africa, two sites in Rio de Janeiro and one site in Sao Paulo, Brazil and one site in Chiang Mai, Thailand Men who have sex with men Truvada (Tenofovir and Emtricitabine) based oral PrEP 44% lower infection rate in the control group and 75 % infection rate in the placebo arm

  4. Integrating Treatment and Prevention Increased VCT with linkage to care Scale-up ARV use starting at CD4 < 350 (maybe higher?) Provide support services: rights protection, adherence, treatment literacy, etc Increased opportunities for other prevention interventions for both HIV+ and HIV-: behavior change, condoms, harm reduction, circumcision, vertical transmission, microbicides

  5. Treatment as Prevention (TasP) is completely dependent on widespread testing, linkage to care, confronting stigma, behavioral reinforcement of safer sex and adherence, etc. It is a complex multi-component intervention and is synergistic with MC, behavioral interventions, microbicides and other prevention strategies.

More Related