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Something we learn from textbook

Dive into the fascinating world of white and brown fat cells as you explore their differences, energy storage, and dissipation mechanisms. Discover the latest progress in "brown conversion" of white fat and the presence of beige fat cells in adult humans, particularly in the neck region. Unravel questions about beige fat cell origins and the distinctions between classical brown fat and beige fat in adult humans. Explore the characteristics and differentiation of beige fat cells and their relationship to white adipose tissue. Learn how sympathetic stimulation impacts the transformation of white fat cells into beige adipocytes.

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Something we learn from textbook

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  1. Something we learn from textbook • White fat cell • Store energy • Monolocular(单房的) • Brown fat cell • Dissipate energy [high mitochondrial UCP1(uncoupling protein 1)] • Multilocular • In small mammals, not in large mammals after infancy

  2. Some new progress • “brown conversion”of white fat • Brown fat in adult humans • UCP1+ • Particularly in supraclavicular and neck region cold or cAMP • White fat tissue • UCP1﹣ • UCP1+ • brown fat cell • UCP1+ • Derived from myf-5 lineage

  3. Questions • Beige fat cell is a distinct cell type or derived from white fat cells ？ • The brown fat tissue in adult human is classical brown fat or beige fat ?

  4. 第一PPT模板网 WAT: white adipose tissue BAT: brown adipose tissue Lecturer: Cao Lijie

  5. Beige adipocyte in white fat Beige fat cell readily detectable in Inguinal subcutaneous fat depot • Multilocular • UCP1 between WAT and BAT BAT Inguinal subcutaneous fat depot Epididymal WAT Brown fat cell-enriched protein

  6. Beige adipocyte in white fat Ing Immortalization(无限增殖) … … cell lines differentiate … … beige fat cell White fat cell Beige fat cell is derived from a subset of precursor cells within white fat.

  7. characteristics of Beige cells (By cAMP) Brown fat-- enriched protein

  8. Brown fat in adult humans are beige fat cells

  9. highlights “Brown” fat in human adults is composed of beige adipocytes subQ WAT White adipogenic cells Beige adipogenic cells Sympathetic stimulation Beige adipocyte

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