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Sham

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Sham

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  1. Supplementary table 1 Echocardiographic assessments of cardiac functions and cardiac morphology in Rnd3+/- and wild-type (WT) control mice under physiology conditions. No significant differences were detected between the two group of mice. d, diastolic; s, systolic; IVS, interventricular septum thickness; LVID, left ventricle inner dimension; LVPW, left ventricle posterior wall thickness. n = numbers of 10- to 15-wk-old male mice used for analysis. Statistical significance was determined by unpaired, two-tailed student’s t test. Data are means ± s.d.

  2. Systolic blood pressure (mmHg) Diastolic blood pressure (mmHg) 5 6 3 4 4 4 TAC TAC +Fasudil Sham WT Rnd3+/- WT Rnd3+/- Supplementary figure 1 Multiple comparisons of systolic and diastolic blood pressures among three groups: Sham, TAC only, and TAC plus Fasudil treatment. No significant differences were detected either between WT and Rnd3+/- mice or among the mice in three groups. Statistical significance was determined by Kruskal-Wallis One Way ANOVA on Ranks followed by Dunn’s method. Data are means ± s.d. 5 6 3 4 4 4 TAC TAC +Fasudil Sham

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