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Three Metabolic Pathways

Three Metabolic Pathways. CELLULAR RESPIRATION. Pathways of Cell Respiration. 2. 2. 34. Glycolysis Summary. NADH H +. PYRUVATE. To ETC. 2 ATP. GLUCOSE. NADH H +. PYRUVATE. Ready to use. Fermentation. Aerobic Cell Resp. Fermentation.

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Three Metabolic Pathways

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  1. Three Metabolic Pathways CELLULAR RESPIRATION

  2. Pathways of Cell Respiration 2 2 34

  3. Glycolysis Summary NADH H+ PYRUVATE To ETC 2 ATP GLUCOSE NADH H+ PYRUVATE Ready to use

  4. Fermentation Aerobic Cell Resp Fermentation • Some orgs lack the O2 or tools necessary for KC or ETC • Leads to buildup of useless pyruvate and NADH • Fermentation • Elimination of pyruvate • Recycling of NAD+ GLYCOLYSIS 2 NAD+ 2 NADH PYR Glucose Glucose PYR 2 ATP

  5. Available for glycolysis Diffuses out of cell Diffuses out of cell Alcohol Fermentation

  6. Alcohol Fermentation Uses

  7. Available for glycolysis Diffuses out of cell Lactic Acid Fermentation

  8. Krebs Preparation(for each of 2 pyruvates) To ETC CoA NADH To Cycle ACETYL CoA PYRUVATE Diffuses Away (Waste) CO2

  9. Krebs Cycle Subsequent rxns break down the citrate into another oxaloacetate. Acetyl CoA (2C) Oxaloacetate (4C) Citrate (6C)

  10. ACETYL CoA 6C 4C 2C CITRATE OXALOACETATE Krebs Cycle 5C NADH 4C NADH ATP NADH FADH2

  11. Glycolysis • Before • Glucose • 2 NAD • 2 ADP + P • After • 2 Pyruvate • 2 NADH • 2 ATP Matrix (Krebs) Matrix (ETC) Where needed

  12. Krebs Cycle (including lead-up steps) • Before • 2 Pyruvate • 8 NAD • 2 FAD • 2 ADP + P • After • 6 CO2 • 8 NADH • 2 FADH2 • 2 ATP Diffuse away IMM (ETC) IMM (ETC) Where needed

  13. ETC  Chemiosmosis

  14. AlternateCatabolism Deamination

  15. Regulation • Phosphofructokinase • Catalyzes one step of glycolysis • Inhibited by • ATP and Citrate • Stimulated by • ADP and AMP • AA production • Inhibited by large amounts of AA’s

  16. Cell Respiration Review Which part of CR? • CO2 is given off • Water is formed • Oxaloacetate • Flavin mononucleotide protein • Pyruvate production • ATP Production

  17. Cell Respiration Review Put the following molecules in order of increasing electronegativity: • Glucose • FADH2 • O2 • NADH • Glucose • NADH • FADH2 • O2

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