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Coagulation Thrombosis

Outline. Hemostatic mechanismStops blood loss due to vessel damageAccomplished by Platelets Coagulation factors (mostly named with roman numerals)Coagulation/thrombosis and biomaterialBlood contacting biomaterials should resist activation of thrombosis and coagulationIn practice, no biomateri

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Coagulation Thrombosis

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    1. Coagulation & Thrombosis Lecture 20 April 2, 2009

    2. Outline Hemostatic mechanism Stops blood loss due to vessel damage Accomplished by Platelets Coagulation factors (mostly named with roman numerals) Coagulation/thrombosis and biomaterial Blood contacting biomaterials should resist activation of thrombosis and coagulation In practice, no biomaterial is perfect Interactions between biomaterials and blood cells & proteins are not well understood in vivo

    3. Hemostasis Hemostatic mechanism is designed to arrest bleeding from injured blood vessels An artificial surface in contact with blood, complex interdependent reactions between: Artificial surface Platelets Coagulation proteins Reactions result in the formation of a clot (thrombosis) which may subsequently undergo removal by fibrinolysis Process is localized at the surface (interface) by activation and inhibition systems Maintain fluidity of blood in circulation

    4. Natural Response to Injury Platelet activation leads to clot formation to stop blood loss

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