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Osteosarcoma DR: Gehan mohamed

Osteosarcoma DR: Gehan mohamed. Osteosarcoma. Definition. Osteosarcoma is an aggressive malignant neoplasm arising from primitive transformed cells of mesenchymal origin (and thus a sarcoma ) that exhibit osteoblastic differentiation and produce malignant osteoid .

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Osteosarcoma DR: Gehan mohamed

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  1. OsteosarcomaDR: Gehan mohamed

  2. Osteosarcoma

  3. Definition • Osteosarcoma is an aggressive malignantneoplasm arising from primitive transformed cells of mesenchymal origin (and thus a sarcoma) that exhibit osteoblastic differentiation and produce malignantosteoid. • It is the most common histological form of primary bonecancerin age 12-25yrs.

  4. Epidemiology • Male more than female • at any age but 75% of cases appear at age 12-25yrs

  5. Risk factors: • Radiation exposure • Patients who survive after taking therapy for another Cancer. • Retinoblastoma(malignant tumor arising from retina of eye).

  6. Sites of predlection: Osteosarcoma :It originates more frequently in the metaphyseal region of tubular long bones, with 42% occurring in the femur

  7. Skeletal distribution : most common at Knee region

  8. osteosarcoma

  9. Histopathologic variants • 1. Conventional: osteoblastic, chondroblastic, fibroblastic • 2. Multifocal • 3. Telangiectatic • 4. Small cell • 5. Intraosseous well-differentiated • 6. Intracortical • 7. Periosteal • 8. Paraosteal • 9. High-grade surface • 10. Extraosseous

  10. Diagnosis of osteosarcoma Clinical examiation Radiologic examinatiom Biopsy for histopathology

  11. Clinical Presentation • Painful mass arising from bone • Metastasize early

  12. Plain Xray • The area of tumor mass may be Lytic, sclerotic or mixed

  13. In x – ray we can see Codman triangle Codman triangle is a term used to describe the triangular area of new subperiosteal bone that is created when a lesion, often a tumour, raises the periosteum away from the bone. sun-burst" appearance on X-ray examination due to the tumor spicules of calcified bone radiating in right angles

  14. Codman triangle

  15. Codman triangle

  16. Local • CT • MRI • +/- Angiogram

  17. Systemic • Bone scan • CT Chest

  18. Osteosarcoma : it is formed of Spindle shaped cells showing malignant criteria in form of pleomorphism,hyperchromasia, abnormal mitosis, giant cells . In between spindle cells there is malignant osteoid.

  19. Differential Dx • Giant Cell Tumor • Aneursymal Bone Cyst • Ewings tumor • Osteoblastoma • Metastasis • Lymphoma

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