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FSH and LH

FSH and LH. Luteinizing Hormone (LH). Follicle Stimulating Hormone STRUCTURES, RECEPTORS AND PATHWAYS.

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FSH and LH

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  1. FSH and LH

  2. Luteinizing Hormone (LH)

  3. Follicle Stimulating HormoneSTRUCTURES, RECEPTORS AND PATHWAYS

  4. Control of the reproductive axis originates in the hypothalamus with the periodic pulsatile release of gonadotropin-releasing hormone (GnRH). In response to GnRH (also called luteinizing hormone-releasing hormone or LHRH), the pituitary releases pulses of the gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), into the blood stream. go·nad·o·tro·pin (gō'nad-ō-trō'pin, gon'ă-dō-), 1. A hormone capable of promoting gonadal growth and function; such effects, as exerted by a single hormone, are usually limited to discrete functions or histologic components of a gonad, such as stimulation of follicular growth or of androgen formation; most gonadotropins exert their effects in both genders, although the effect of a given gonadotropin will differ in males and females. 2. Any hormone that stimulates gonadal function. 3. Any substance that has the combined effects of follicle-stimulating hormone and luteinizing hormone.

  5. :Luteinizing Hormone • Males: stimulates testosterone production in males • Females: triggers ovulation and stimulates progesterone secretion • Structure: Heterodimeric glycoprotein with 2 subunits • α (92 amino acids) – same as α subunits in FSH, TSH & hCG • β (120 amino acids) – binds with LH receptors • Secreted in anterior pituitary after stimulation from the hypothalamus via GnRH (gonadotropin-releasing hormone) • Shares same pathway of secretion as FSH • Regulated in negative feedback loop in men, and both negative and positive feedback loop in women

  6. LH Triggers Puberty • LH and FSH levels are elevated from birth until 6 months • Development of secondary sex characteristics (puberty) is triggered by LH • During puberty, hypothalamus secrete more GnRH • ⇧ GnRH => ⇧ LH (and FSH) => ⇧ sex steroid hormones => development of secondary sex characteristics

  7. Testes have 2 main “compartments: • Seminiferous tubules – Sertoli cells for spermatogenesis • Interstitial tissue – Leydig cells for testosterone secretion

  8. Follicular Phase: • FSH stimulates growth of follicle which stimulates estradiol secretion • Increase in FSH & estradiol stimulates production of LH receptors on graafian cells during late follicular phase • LH surge: rise in estradiol increases frequency of GnRh pulses and increases ability of pituitary to respond to GnRH with ⇧LH (positive feedback) • Ovulation: • LH surge causes graafian follicle to burst • Luteal Phase: • LH stimulates empty follicle to become restructured into corpus luteum and secrete progesterone in addition to estradiol • Increase in progesterone inhibits GnRH, which inhibits LH & FSH (negative feedback) • Fall in ovarian hormones causes menstruation

  9. ENDOGENOUS PATHWAY OF FSH IN FEMALES

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