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Fluids Management. Jamal A. Alhashemi, MBBS, MSc , FRPC, FCCP, FCCM Professor of Anesthesiology & Critical Care Medicine Faculty of Medicine, King Abdulaziz University. Objectives. By the end of the lecture, students should be able to: Compare crystalloids with colloids
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Fluids Management Jamal A. Alhashemi, MBBS, MSc, FRPC, FCCP, FCCM Professor of Anesthesiology & Critical Care Medicine Faculty of Medicine, King Abdulaziz University
Objectives • By the end of the lecture, students should be able to: • Compare crystalloids with colloids • Determine the volume status of patients based on clinical exam & invasive monitors • Institute appropriate fluid therapy for the resuscitation of trauma patients
Case History • A 24 yr old male involved in an MVC 1/2 h ago as an unrestrained driver. His primary survey revealed fractured left femur but no other injuries. In ER, his HR 120/min, BP 70/40, RR 24, SpO2 100% on FiO2 0.5 by facemask.
What are the issues? • Shock • Tachypnea • Fractured femur, ongoing bleeding • Potential C-spine injury • Potential closed head injury
What should you do next? • ABC • Volume resuscitation • Which type of fluid? • How fast? • How much? How do we know? • ? Vasopressors
Crystalloids: 0.9% NaCl (NS) 0.45% NaCl 0.225% NaCl 3% NaCl Lactated Ringer 5% Dextrose (D5W) D5 LR D5 NS D5 1/2NS D5 1/4NS 10% Dextrose (D10) 25% Dextrose (D25) 50% Dextrose (D50) Types of Fluids
Colloids: 6% HES 5% Albumin Plasma Protein Fraction (PPF) Fresh Frozen Plasma (FFP) Whole Blood Gelatins Types of Fluids
Body Fluid Composition ICF (2/3) ECF (1/3) ISF (2/3) IVF (1/3) H2O H2O H2O Na+ Na+ Cl - Cl - HES
Crystalloids Cheap Readily available Large volume Maintenance & resuscitation fluid No allergic potentials No infectious risk Colloids Expensive Not readily available Small volume Resuscitation fluid Not for maintenance Potential for allergy Risk of infection Crystalloids vs. Colloids
Fluid Therapy • Maintenance Therapy • 4 ml/kg/h • 2 ml/kg/h • 1 ml/kg/h • Deficit • Replace as fast as possible • 3:1 rule when giving crystalloids • Ongoing losses including “third spacing” • Fluid therapy = maintenance + deficit + losses
Monitoring of Fluid Therapy • Clinical exam • HR • MAP • ?JVP and “postural drop” • Urine output • Central venous pressure (CVP) • Pulmonary artery catheter (PAOP) • Serum lactate & ScvO2
Goals of Therapy - I • MAP ≥ 65 mmHg • HR < 100/min • Urine output • Adults ≥ 0.5 ml/kg/h • Pediatrics ≥ 1 ml/kg/h • ScvO2 ≥ 70% • Serum lactate ≤ 2 mmol/l
Goals of Therapy - II • CVP • CVP 8-12 mmHg • 5, 7 rule • PA catheter • PAOP 10-12 mmHg • 2, 5 rule • Trends are more important than absolute numbers
Complications of Fluid Therapy • Fluid overload • Generalized edema • Pulmonary edema • Electrolyte disturbances • Na+ • K+ • Ca++ • Hypothermia • Coagulopathy
Case Management - I • ABC • Two large-bore iv cannulae • CBC, coags, urea & electrolytes • X-match 4-6 units of PRBCs • LR for initial resuscitation
Case Management - II • HES may be added subsequently • Blood may be needed later • Early blood administration if there is ongoing uncontrolled hemorrhage • FFPs only for documented coagulopathy
Conclusion - I • Most of the hypotension encountered in the surgical patient is due to hypovolemia • Never use hypotonic solutions for fluid resuscitation • Never use dextrose-containing solutions for fluid resuscitation
Conclusion - II • Never use FFP for fluid resuscitation • Blood may be used for severe hemorrhage or uncontrolled bleeding • Always monitor the adequacy of fluid resuscitation