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General Overview. The Research Experience itselfMy role in the Tissue Engineering LabConclusions
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1. Coming Attractions Coming Soon … …to your local high school Emerging Technologies in Science: Tissue Engineering by Mary Coleman – Overbrook High School
2. General Overview The Research Experience itself
My role in the Tissue Engineering Lab
Conclusions – What I Learn
Curriculum Project
3. Dr Sun’s Computer Aided Tissue Engineering Lab Computer aided Tissue Engineering lab was composed of a team working on the bone-tissue interface with different aspects of the problem.
Overall goal of TE is to reconstruct or correct some limiting aspects of the human condition.
Quest for the “Fountain of Youth” is here.
4. Tissue Engineering
This technology involves removing cells from a healthy
part of the body and placing them in an area of diseased or damaged tissue in order to improve certain body functions.
Currently, it is used to treat defects in cartilage, and, if successful, could eventually help treat osteoarthritis.
Hence, the topic of osteoarthritis and the knee joint cartilage is selected for research study.
5. STRUCTURE OF THE KNEE Can you locate the areas of the knee where tissue engineering will be useful?
6. My Role in the Lab Computer Aided Tissue Engineering begins with the computer and learning Mimics Software
Made a 3-D model of the Knee joint using Mimics (Show Model)
Observed extruder making scaffolds for tissues
Presented a Research Paper on Knee with Notebook of articles used for future use by staff
7. Mimics Software 3-D Image Used to Construct Mold of Knee Joint
8. Simulation of Cartilage Cell Seeking Bone Scaffold Graphic Courtesy of Andrew Darling, Dr Sun Laboratory, Drexel University
9. What I Learned from Research
10. School District of Philadelphia Curriculum Project Standards Pa Standards for Science and Technology
Living Environment 14.7: Students will understand that increased human life expectancy has resulted from advances in health technology, agriculture, and manufacturing. (14.7.1) Understand that advances in medical science, biotechnology, improved sanitation enhances quality of life of humans.
Science and Technology Standard 3.6.10 99 (A) Apply knowledge of Biomedical Technology applications in designing a solution to a simple medical problem. (B) Apply appropriate instruments and apparatus to examine a variety of objects and processes.
11. Curriculum Project (excerpts only- Refer to hand out for complete Unit) Overarching Unit Goal
Is it possible for Biotechnology through Tissue Engineering to reconstruct knee cartilage if has worn out or been damaged?
12. Curriculum Project Unit Long Understanding Goals How does a normal knee joint work ? (include tissues, bones, muscles)
What happens in the functioning of a diseased joint ?
How are people of different ages affected by knee injuries and what corrective measures are taken?
What types of bone scaffolds can different cell types be grown on?
13. Introductory Performance a. Students will view video: Dateline current clinical cases on knee replacements.
b. Students will break up into groups and discuss case histories and find out what experiences people have had with knee injuries
c. Invite speaker from Drexel Medical School to talk on local knee surgeries and injuries.
On-going Assessments for Introductory Performance
a. Students will write a 2 paragraph reaction to video. Agree or disagree with clinical cases.
b. Students will write up what they know and want to know about knee injuries (KWL)
14. Guided Inquiry Performance Understanding Performances Students will construct a model showing bones, muscles, and tendons of the knee joint using clay or construction paper
Students will examine a knee joint model showing normal, mild, moderate, and severe knee joint damage.
Students will use the microscope to examine the different cell types.
Students will go online to various web sites to see Electron Micrographs of different cell types
15. On Going Assessments for Understanding Performances Students will present their knee joint model
Students will present ideas on the various conditions of knee damage and what the consequences are.
Students will draw cells from using the microscope and speculate on how tissues are made
16. Curriculum Project Culminating Performance Students will take a field trip to tissue engineering
lab and will make a mold
Students will complete KWL with what they learned
17. Why should High School Biology Students learn about Emerging Technologies? Future Careers in the multidisciplinary fields of Biology and Engineering that will solve relevant scientific problems
Become better prepared for College Studies
Greater understanding of future developments in curing a disease or condition where tissue engineering may affect your life.
Anticipate fewer deaths due to lack of organs for transplants may be possible through tissue engineering
Increased application and development of computer skills
18. Acknowledgements Many thanks to Dr. Sun and his graduate students for allowing me into their lab
Dr. Corey Ruth – Keystone Orthopedics, Graduate Hospital for providing Knee Models and for his interest in working with alternative therapies for knee replacements
RET Program at Drexel – Joanne Ferroni for the excellent assistance and training on Power Point.
All my RET colleagues who gave me extra help and assistance
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20. Simulation of Cartilage Cell Seeking Bone Scaffold Graphic courtesy of Andrew Darling, Dr. Sun Laboratory- Drexel University
