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Membrane Bilayer – Sea of Phospholipids

Membrane Bilayer – Sea of Phospholipids. Phospholipids Able to move laterally and transversely (flip-flop) Hydrophobic Tails Hydrophilic Heads Water in Cytosol (Inner Leaflet) Water in Extracellular matrix (Outer Leaflet). Proteins Move Laterally, NOT transversely (flip-flop)

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Membrane Bilayer – Sea of Phospholipids

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  1. Membrane Bilayer – Sea of Phospholipids

  2. Phospholipids Able to move laterally and transversely (flip-flop) Hydrophobic Tails Hydrophilic Heads • Water in Cytosol (Inner Leaflet) • Water in Extracellular matrix (Outer Leaflet)

  3. Proteins Move Laterally, NOT transversely (flip-flop) Integral Proteins –Transverse the membrane • Channels for Passive Transport • Pumps for Active Transport • Cell Adhesion Proteins • Membrane-bound Enzymes (such as The Electron Transport Chain on the Cristae of Mitochondria) Peripheral Proteins – Attach to only one leaflet or membrane layer • Antigens • Hormone Receptors

  4. Carbohydrates Glycoproteins – peripheral proteins that have a carbohydrate group attached • Carbohydrate always attaches to Outer Leaflet

  5. Cholesterol Abundant in plasma membrane ↑ Cholesterol = ↓ fluidity ↑ Cholesterol = ↓ permeability

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