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The Blood Clotting Cascade

The Blood Clotting Cascade. Manfred Maitz FZ-Rossendorf www.manfred.maitz-online.de. Thrombin. Fibrin polymers. Fibrin monomers. Fibrinogen. The Clotting Cascade. Intrinsic Pathway. Extrinsic Pathway. Surface Contact Collagen FXII activator. Tissue/Cell Defect. F XII. F XIIa.

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The Blood Clotting Cascade

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  1. The Blood Clotting Cascade Manfred MaitzFZ-Rossendorf www.manfred.maitz-online.de

  2. Thrombin Fibrinpolymers Fibrinmonomers Fibrinogen The Clotting Cascade

  3. Intrinsic Pathway Extrinsic Pathway Surface Contact Collagen FXII activator Tissue/Cell Defect F XII F XIIa F VIIa F VII Ca2+ F XI F XIa Ca2+ F IX F IXa F III (Tissue Thromboplastin) Ca2+ F VIII F VIIIa Platelet Factor 3 Factor F X Factor F Xa Factor F X Ca2+ Ca2+ F Va F V Prothrombin I Thrombin Ca2+ F XIIIa F XIII Fibrinpolymers Fibrinmonomers Fibrinogen CrosslinkedFibrin Meshwork The Clotting Cascade

  4. RN RN Ser O- Ser C :O O O C H HN H HN Tetraedric Transition State RC RC Break of the Peptide Bonding HN H RC RN RN H2O C Ser :OH Ser O C O OH O Release of the N-terminal peptide Enzyme-acetyl-transition-state Serine Proteases

  5. The Fibrinolytic System Clotting Cascade Fibrin degradation products Fibrinogen Fibrin-clot Plasminogen Plasmin T-PAF XIIaHMWKKallikreinUrokinaseStreptokinase

  6. F Va F V Effect of Antithrombin III/Heparin Intrinsic Pathway Extrinsic Pathway Surface Contact Collagen FXII activator Tissue/Cell Defect F XII F XIIa F VIIa F VII Ca2+ F XI F XIa Ca2+ F IX F IXa F III (Tissue Thromboplastin) Ca2+ F VIII F VIIIa Platelet Factor 3 Factor F X Factor F Xa Factor F X Ca2+ Ca2+ Prothrombin I Thrombin Ca2+ F XIIIa F XIII Fibrinpolymers Fibrinmonomers Fibrinogen CrosslinkedFibrin Meshwork

  7. F Va F V Thrombin Time (TT) Intrinsic Pathway Extrinsic Pathway Surface Contact Collagen FXII activator Tissue/Cell Defect F XII F XIIa F VIIa F VII Ca2+ F XI F XIa Ca2+ F IX F IXa F III (Tissue Thromboplastin) Ca2+ F VIII F VIIIa Platelet Factor 3 Factor F X Factor F Xa Factor F X Ca2+ Ca2+ Prothrombin I Thrombin Ca2+ F XIIIa F XIII Fibrinpolymers Fibrinmonomers Fibrinogen CrosslinkedFibrin Meshwork

  8. The Quick (PT)-Test Intrinsic Pathway Extrinsic Pathway Surface Contact Collagen FXII activator Tissue/Cell Defect F XII F XIIa F VIIa F VII Ca2+ F XI F XIa Ca2+ F IX F IXa F III (Tissue Thromboplastin) Ca2+ F VIII F VIIIa Platelet Factor 3 Factor F X Factor F Xa Factor F X Ca2+ Ca2+ F Va F V Prothrombin I Thrombin Ca2+ F XIIIa F XIII Fibrinpolymers Fibrinmonomers Fibrinogen CrosslinkedFibrin Meshwork

  9. Partial Thromboplastin Time [(a)PTT] Intrinsic Pathway Extrinsic Pathway Surface Contact Collagen FXII activator Tissue/Cell Defect F XII F XIIa F VIIa F VII Ca2+ F XI F XIa Ca2+ F IX F IXa F III (Tissue Thromboplastin) Ca2+ F VIII F VIIIa Platelet Factor 3 Factor F X Factor F Xa Factor F X Ca2+ Ca2+ F Va F V Prothrombin I Thrombin Ca2+ F XIIIa F XIII Fibrinpolymers Fibrinmonomers Fibrinogen CrosslinkedFibrin Meshwork

  10. F Va F V Surface Sensitive Steps Intrinsic Pathway Extrinsic Pathway Surface Contact Collagen FXII activator Tissue/Cell Defect F XII F XIIa F VIIa F VII Ca2+ F XI F XIa Ca2+ F IX F IXa F III (Tissue Thromboplastin) Ca2+ F VIII F VIIIa Platelet Factor 3 Factor F X Factor F Xa Factor F X Ca2+ Ca2+ Prothrombin I Thrombin Ca2+ F XIIIa F XIII Fibrinpolymers Fibrinmonomers Fibrinogen CrosslinkedFibrin Meshwork

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