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Blood Clotting Process and Potential Risks

Discover the intricate process of blood clotting in human biology, a protective mechanism triggered by cell damage to reduce blood loss from wounds. Understand how the release of clotting factors leads to the conversion of prothrombin to thrombin and fibrinogen to fibrin, forming a clot. Learn about thrombosis, embolus, and the potential risks like coronary thrombosis leading to heart attacks and strokes.

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Blood Clotting Process and Potential Risks

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  1. Clotting of Blood Higher Human Biology

  2. Blood Clotting • Protective • Triggered by damage to cells • (Normally) to reduce loss of blood from wounds

  3. Presence of damaged cells leads to release of blood clotting factors • Prothrombin(always present in blood plasma) converted to thrombin • Promotes conversion of fibrinogen (soluble plasma protein) to threads of fibrin (insoluble protein) • Interweave to framework • Platelets adhere • Blood clot

  4. Thrombosis • As atheromas eventually increase in size it may damage endothelium • This may lead to thrombosis • Formation of a blood clot (thrombus) in a vessel

  5. Embolus • Thrombus which has broken loose • Carried along until it blocks some narrow vessel

  6. If this happens in a coronary artery • Coronary thrombosis • May lead to myocardial infarction (heart attack) • If this happens in an artery in the brain • Stroke

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