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iGEM & Synthetic Biology International Genetically Engineered Machine Competition

iGEM & Synthetic Biology International Genetically Engineered Machine Competition. Randy Rettberg igem2007.com parts.mit.edu. SB 3.0 Zurich 6/24/07. An Engineering Question. Can simple biological systems be built from standard, interchangable parts and operated in living cells?

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iGEM & Synthetic Biology International Genetically Engineered Machine Competition

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  1. iGEM & Synthetic BiologyInternational Genetically Engineered Machine Competition Randy Rettberg igem2007.com parts.mit.edu SB 3.0 Zurich 6/24/07

  2. An Engineering Question Can simple biological systems be built from standard, interchangable parts and operated in living cells? Or, is biology so complex that each case is unique?

  3. Education Driving Research

  4. International Genetically Engineered Machine Competition 2005 • 13 Schools Caltech MIT UC Berkeley Cambridge, UK Oklahoma UCSF Davidson Penn State UT Austin ETH, Zurich Princeton Harvard Toronto, Canada • Sponsored by Microsoft/MIT iCampus

  5. iGEM 2006 • 40 Schools, 33 Teams • 450 participants • Europe, Canada, Asia, Latin America, US • Some EU funding in place • iGEM ambassadors for US, Asia, and Europe • Jamboree November 4 & 5 • www.iGEM2006.com • Supported by Microsoft Research and iCampus

  6. iGEM 2006 Ege University, Turkey

  7. www.iGEM2006.com

  8. Meet the Teams

  9. Valencia iGEM Site

  10. iGEM 2006 Results

  11. Sample iGEM Projects Berkeley Controlled Communications Davidson Flipping DNA Harvard DNA Boxes ETH Zurich Pattern Matching Ljubljana Controlling Sepsis Chiba Japan Light-Directed Chemotaxis Mississippi Hydrogen Gas Detector MIT Banana and Wintergreen Smells Edinburgh Arsenic Detector

  12. MIT iGEM 2006 eau d’e coli mit igem 2006

  13. The field test device A test tube could contain all the necessary components: Freeze dried bacteria, growth medium, indicator powder, Ampicillin salt, etc… • These tubes could then be given to local villagers to monitor their own water quality themselves • A good alternative to the widely used Gutzeit method www.Macteria.co.uk

  14. Some Engineering Answers Can simple biological systems be built from standard, interchangable parts and operated in living cells? - YES, SOMETIMES Or, is biology so complex that each case is unique? - NOT ALWAYS

  15. www.igem2007.com

  16. Financial Resources Small Sample: $20K 8 $30K 8 $40K 1 $50K 4 >$50K 2

  17. iGEM 2007 and Beyond • 2008: 100 Schools -> Partition? • Geographic Competitions • Tracts • Health and Medicine • Energy and the Environment • Parts and Devices • Fun and Games • Sensors • Other

  18. The Impact of iGEM Students Making future synthetic biologists Teaching graceful competition Instructors Opportunities for junior faculty New programs - new ideas A task worth the effort Schools Synthetic biology entering curriculum Energize research programs Synthetic Biology Examples, parts, successes, testamonials

  19. Registry of Standard Biological Parts An industry based on standard parts requires catalogues and suppliers of those parts.

  20. Registry PartsCatalog http://parts.mit.edu

  21. Promoters Protein Coding Reporters RNA Terminators Signaling Many project parts Registry Contents 7/2007 1400 Parts Available as DNA

  22. Part Characterization Constitutive Promoters - Berkeley

  23. DNA Repository

  24. DNA Repository • All parts sent to teams • Parts are from previous teams

  25. Robotic Assembly

  26. DNA Synthesis Offer GENEART synthetic DNA offer for iGEM teams • All you want at $0.70 per base • 100,000 bases total at $0.25 per base • About 2000 bases per team for $500 • GENEART is a primary sponsor of iGEM 2007 http://www.geneart.com/index.php?id=252

  27. New Programs BioBrick Part Program iGEM in Europe Registry in Europe New Registry Workshop Standards Workshop iGEM Steering Committee

  28. Standards • Device Families • Protein : DNA logic • Post-translational control • RNA-based control • Localization • Measurement • Input and Outputs • (PoPS - Polymerase Per Second) • Genetic stability • Cross-lab consistency • Operating Environment • Load on the cell • Environmental impact on performance • Models

  29. Sponsors • National Science Foundation • SynBERC • CSBi • GENEART • Microsoft Research • Biological Engineering - MIT

  30. Teachers Workshops MIT May 26th China June 16-17 Zurich June 27th • Hands-on training • Future instructors welcome

  31. How can I participate? • Organize a team for 2008 • Volunteer for the BioBrick parts program. • Join the Awards committee • Be a judge • Have your lab join the Registry • Contribute parts to the Registry • Use BioBrick part standards • Help raise money for teams and ambassadors in your area. • Join iGEM committees (see the wiki) • Join iGEM in Europe

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