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#457 Sweep Imaging with Fourier Transform (SWIFT) in Breast Cancer

#457 Sweep Imaging with Fourier Transform (SWIFT) in Breast Cancer Curtis A. Corum , Andrew Babcock, Djaudat Idiyatullin, Angela L. Styczynski-Snyder, Diane Hutter, Lenore Everson, Michael Nelson, and Michael Garwood University of Minnesota, Minneapolis, MN, United States.

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#457 Sweep Imaging with Fourier Transform (SWIFT) in Breast Cancer

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  1. #457 Sweep Imaging with Fourier Transform (SWIFT) in Breast Cancer Curtis A. Corum, Andrew Babcock, Djaudat Idiyatullin, Angela L. Styczynski-Snyder, Diane Hutter, Lenore Everson, Michael Nelson, and Michael Garwood University of Minnesota, Minneapolis, MN, United States

  2. #457 Breast SWIFT, Curt Corum Declaration of Relevant Financial Interests or Relationships Speaker Name: Curtis A. Corum I have the following relevant financial interest or relationship to disclose with regard to the subject matter of this presentation: Dr. Corum is entitled to sales royalties under an agreement between the University of Minnesota and GE Healthcare, which is developing products related to the research described in this paper. The University of Minnesota also has a royalty interest in GE Healthcare. These relationships have been reviewed and managed by the University of Minnesota in accordance with its Conflict of Interest policies.

  3. #457 Breast SWIFT, Curt Corum Breast MRI While many MRI sequence types are sometimes indicated in Breast MRI the two main image sets usually desired are: High spatial resolution pre and post-contrast T1 weighted images (and subtractions) for morphological assessment (circumscribed vs spiculated, homogeneous vs heterogeneus enhancing, etc.) High temporal resolution dynamic contrast enhanced (DCE) T1 weighted image series with at least 1 min temporal resolution for contrast kinetics (uptake vs washout) Emerging standard of care utilizes semi and fully-quantitative pharmacokinetic modelling, with active research in improving models

  4. #457 Breast SWIFT, Curt Corum SWIFT SWeep Imgaing with Fourier Transform Simultaneous interleaved excitation and acquisition 3D Radial Sampling (Halton sequence) PD or T1 weighted Smooth Gradient Update (Quiet) robust against motion, eddy currents, and system timing

  5. #457 Breast SWIFT, Curt Corum SWIFT SWeep Imgaing with Fourier Transform Simultaneous interleaved excitation and acquisition 3D Radial Sampling (Halton sequence) PD or T1 weighted Smooth Gradient Update (Quiet) robust against motion, eddy currents, and system timing

  6. #457 Breast SWIFT, Curt Corum SWIFT Timing SWIFT has extremely short dead time On the order of 2-6 μs Sensitive to fast relaxing spins Preserves signal from off resonant spins

  7. #457 Breast SWIFT, Curt Corum 4 T SWIFT Breast Coils Modified Single Breast Coils2 ch Transmit/Receive, 4 TCMRR Carl SnyderHelmut Merkle (now at NIH)Currently in use SWIFT compatible Dual Breast Coil4 ch Transmit/Receive, 4 TUMN Physics Machine Shop, Peter NessCMRR Gregor Adriany, Carl SnyderNow in imaging testing

  8. #457 Breast SWIFT, Curt Corum Halton View Order Pseudo Random 3d radial view-ordering Sorted for smooth gradient transition Full sphere coverage every 512 views Designed for View Sharing and CS reconstruction

  9. #457 Breast SWIFT, Curt Corum Goals Implement SWIFT based protocol for Breast MRI SWIFT compatible (no short T2 background from polymers, fast switching and/or ring-down times) transcieve coil(s) Demonstrate high temporal resolution SWIFT DCE imaging Demonstrate high spatial resolution morphological pre and post contrast imaging from same scan data Scan an initial cohort of patient volunteers

  10. #457 Breast SWIFT, Curt Corum SWIFT Protocol 2 min shimming, pre-scan, scout 20 sec SWIFT pre-scans, phase reference and gain 1-2 min SWIFT FOV check, FS (2-4 min) (optional) Double Angle Method GRE B1 map (2-4 min) (optional) SWIFT Variable Flip Angle T1 map 2-6 min SWIFT DCE FS, pre-contrast (MagnavistTM 0.1 mM/kg at 2 cc/s) 6 min SWIFT DCE FS post-contrast, (optional) further SWIFT test scans 11.33 min Minimum total time

  11. #457 Breast SWIFT, Curt Corum 4 T SWIFT Parameters TR 4.4 ms, 62 kHz, 4.1 ms HS1, Flip 8-16 deg, 256 points Fat Suppression (FS)1/8 views, 4 ms Gauss, Flip 120 deg, offset -625 Hz 3d Radial Isotropic Vieworder Sorted Halton** sequence, 512 views per k-space sphere 128 full spheres per 4.5 min acquisition (6 min with FS) 65,536 views total before restarting Gridding based reconstruction Sliding window reconstruction for DCE, 6 sec frames * 10 ms HS4 R20 pulse for dual fat and silicone suppression ** Wong TT, Sampling with Hammersley and Halton Points,J Graph Tools archive, Volume 2 , Issue 2, 1997., Chan RW et al., MRM 2010.

  12. #457 Breast SWIFT, Curt Corum Case FA

  13. #457 Breast SWIFT, Curt Corum Case mass like DCIS

  14. #457 Breast SWIFT, Curt Corum Case IDC

  15. #457 Breast SWIFT, Curt Corum Ongoing Study... We have now recruited 12 patients and have 8 successful sessions 3 of the incompletes were due to last minute exclusions one due to scanner failure

  16. #457 Breast SWIFT, Curt Corum Conclusions • SWIFT can produce high temporal resolution DCE and high resolution morphological data from the same scan data Work in progress.... • Model based evaluation of DCE data • Compressed Sensing reconstruction • Case reviews and search for novel contrast (short T2) • Continue recruiting patients....

  17. #457 Breast SWIFT, Curt Corum Acknowlegdements We gratefully acknowledge NIH R21 CA139688, P41 RR008079, S10 RR023730, S10 RR027290,and the Minnesota Medical Foundation 3932-9227-09for grant support. Thanks to physicians and residents at the Fairview University Breast Center and Jinjin Zhang for assistance with patient studiesThanks to S. Suddarth and A. Rath of Agilent, B. Hannah,J. Strupp, and P. Anderson of CMRR for software and hardware support. Thanks especially to Djaudat Idiyatullin, Mike Garwood, Mike Tesch, and Ryan Chamberlain (The rest of the SWIFT team) and colleagues at the UMN CMRR!

  18. #457 Breast SWIFT, Curt Corum NMR and Convolution x(t) RF pulse h(t) spin impulse response r(t) = system response * NMR and Convolution The fundamental basis of SWIFT signal processing is that a frequency modulated pulse alters the system response away from the familiar hard pulse impulse response. In the small flip angle limit the relationship is convolution. Practically it works well up to 90°.

  19. #457 Breast SWIFT, Curt Corum SWIFT and Correlation x(t) RF pulse r(t) system response h(t) spin impulse response = Recovering a standard FID by correlation SWIFT produces an FID if the raw data (system reposnse) is correlatied with the complex RF pulse shape as a post processing step. In practice this is performed in the frequency domain by multiplication with the complex conjugate of the complex pulse profile.

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