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Atherosclerosis

The Atherosclerotic Plaque: Soft, severely thrombogenic atheromatheous core covered by fibrous cap. CAM  monocyte adhesion. Chemoattractants mediate monocyte migration into intima. The scavenger receptors mediate uptake of mLDL particles  development into Foam Cells.

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Atherosclerosis

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  1. The Atherosclerotic Plaque:Soft, severely thrombogenic atheromatheous core covered by fibrous cap CAM  monocyte adhesion. Chemoattractants mediate monocyte migration into intima. The scavenger receptors mediate uptake of mLDL particles  development into Foam Cells Endothelial injury allows Lipoprotein particles (LDL) to enter the intima Diffusion distance > limit for passive diffusion Vascular endothelium Network of microvessels formed in adventitia surrounding the lesion growing inwards over time =Neovasculature Internal elastic lamina Smooth muscle cells Inside the arterial wall, blood monocytes encounter M-CSF   expression of scavenger receptors Intimal smooth muscle cells divide   extracellular matrix  matrix accumulation into fibrous cap Foam Cells  cytokinesSmooth muscle cell recruitment   intimal thickness mLDL  local cytokine elaboration   expression of Cellular Adhesion Molecules (CAM) production of chemoattractantsElaboration of Monocyte Colony Stimulating Factor (M-CSF) LDL is modified by oxidation/glycation into Modified Lipoprotein Particles (mLDL) Time Atherosclerosis Lumen IntimaMedia Hypoxia

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